Zangmo Rinchen, Singh Neeta, Kumar Sunesh, Vanamail Perumal, Tiwari Abanish
Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, New Delhi, India.
Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, New Delhi, India.
Reprod Biomed Online. 2014 Jun;28(6):743-7. doi: 10.1016/j.rbmo.2014.01.019. Epub 2014 Feb 25.
The purpose of this study was to evaluate the role of dehydroepiandrosterone (DHEA) on the number and quality of oocytes and embryos in poor responders undergoing IVF cycles. A total of 50 patients with a history of poor ovarian response in the previous cycle(s) were enrolled in a prospective cohort study. They were treated with oral micronized DHEA 25mg three times a day for 4 months. Oocyte and embryo number and quality were recorded before and after treatment. The results were analysed using Student's paired t-test. After treatment with DHEA, a significant increase in number of mature follicles was seen in the post treatment period (⩽ 35 years P<0.001; ⩾ 36 years P = 0.002). There were significant increases in numbers of oocytes retrieved, fertilization rates and, consequently, the total number of embryos available. More embryos were vitrified among patients ⩽ 35 years (P<0.001) post treatment, and clinical pregnancy rate in this group was 26.7%. DHEA treatment resulted in a higher number of oocytes retrieved, oocytes fertilized, embryos overall and of grade-I embryos. It can help in increasing pregnancy rate in poor responders. This study was performed to evaluate the role of dehydroepiandrosterone (DHEA) treatment on the number and quality of oocytes and embryos in poor responders undergoing IVF cycles. Fifty patients with a history of poor ovarian response in the previous cycle(s) were enrolled in the study and a prospective cohort study was performed. Patients were prescribed oral micronized DHEA 25mg three times a day for 4 months. Oocytes and embryos in terms of both number and quality were measured before and after treatment. A significant increase in mean number of mature follicles was seen in the post-treatment group. There was a significant increase in the number of oocytes retrieved, fertilization rates and, consequently, in the total number of embryos available after treatment with DHEA. More embryos were vitrified post treatment and the overall pregnancy rate was 20%. DHEA resulted in a significant improvement in the numbers of oocytes retrieved, oocytes fertilized, embryos and grade-I embryos. DHEA can help improve pregnancy rate in poor responders with history of previous failed IVF cycles.
本研究的目的是评估脱氢表雄酮（DHEA）对接受体外受精（IVF）周期的低反应者卵母细胞和胚胎数量及质量的作用。共有50例在上一周期有卵巢低反应病史的患者纳入一项前瞻性队列研究。他们接受口服微粒化DHEA，每日3次，每次25mg，共治疗4个月。记录治疗前后的卵母细胞和胚胎数量及质量。结果采用配对t检验进行分析。用DHEA治疗后，治疗后期成熟卵泡数量显著增加（≤35岁，P<0.001；≥36岁，P = 0.002）。取到的卵母细胞数量、受精率以及由此可得的胚胎总数均显著增加。治疗后，≤35岁的患者中有更多胚胎被玻璃化冷冻（P<0.001），该组的临床妊娠率为26.7%。DHEA治疗使取到的卵母细胞数量、受精的卵母细胞数量、总的胚胎数量以及I级胚胎数量增加。它有助于提高低反应者的妊娠率。本研究旨在评估脱氢表雄酮（DHEA）治疗对接受IVF周期的低反应者卵母细胞和胚胎数量及质量的作用。50例在上一周期有卵巢低反应病史的患者纳入本研究并进行了一项前瞻性队列研究。给患者开了口服微粒化DHEA，每日3次，每次25mg，共治疗4个月。在治疗前后对卵母细胞和胚胎的数量及质量进行了测量。治疗后组中成熟卵泡的平均数量显著增加。用DHEA治疗后，取到的卵母细胞数量、受精率以及由此可得的胚胎总数均显著增加。治疗后有更多胚胎被玻璃化冷冻，总体妊娠率为20%。DHEA使取到的卵母细胞数量、受精的卵母细胞数量、胚胎数量及I级胚胎数量有显著改善。DHEA有助于提高有既往IVF周期失败病史的低反应者的妊娠率。
