Lin Li-Te, Tsui Kuan-Hao
Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung 81362, Taiwan.
Institute of BioPharmaceutical Sciences, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan.
J Clin Med. 2021 Mar 15;10(6):1211. doi: 10.3390/jcm10061211.
The relationship between serum dehydroepiandrosterone sulphate (DHEA-S) and anti-Mullerian hormone (AMH) levels has not been fully established. Therefore, we performed a large-scale cross-sectional study to investigate the association between serum DHEA-S and AMH levels. The study included a total of 2155 infertile women aged 20 to 46 years who were divided into four quartile groups (Q1 to Q4) based on serum DHEA-S levels. We found that there was a weak positive association between serum DHEA-S and AMH levels in infertile women (r = 0.190, < 0.001). After adjusting for potential confounders, serum DHEA-S levels positively correlated with serum AMH levels in infertile women (β = 0.103, < 0.001). Infertile women in the highest DHEA-S quartile category (Q4) showed significantly higher serum AMH levels ( < 0.001) compared with women in the lowest DHEA-S quartile category (Q1). The serum AMH levels significantly increased across increasing DHEA-S quartile categories in infertile women ( = 0.014) using generalized linear models after adjustment for potential confounders. Our data show that serum DHEA-S levels are positively associated with serum AMH levels.
血清硫酸脱氢表雄酮（DHEA-S）与抗苗勒管激素（AMH）水平之间的关系尚未完全明确。因此，我们开展了一项大规模横断面研究，以调查血清DHEA-S与AMH水平之间的关联。该研究共纳入了2155名年龄在20至46岁之间的不孕女性，她们根据血清DHEA-S水平被分为四个四分位数组（Q1至Q4）。我们发现，不孕女性血清DHEA-S与AMH水平之间存在弱正相关（r = 0.190，P < 0.001）。在对潜在混杂因素进行校正后，不孕女性血清DHEA-S水平与血清AMH水平呈正相关（β = 0.103，P < 0.001）。与血清DHEA-S四分位数最低组（Q1）的女性相比，血清DHEA-S四分位数最高组（Q4）的不孕女性血清AMH水平显著更高（P < 0.001）。在校正潜在混杂因素后，使用广义线性模型分析发现，不孕女性血清AMH水平随着DHEA-S四分位数组的增加而显著升高（P = 0.014）。我们的数据表明，血清DHEA-S水平与血清AMH水平呈正相关。
