Zhuang Zhi-guo, Zhang Xue-bin, Han Jing-feng, Beilner Janina, Deuerling-Zheng Yu, Chi Jia-chang, Wang Ji, Qian Li-jun, Zhou Yan, Xu Jian-rong
Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Healthcare Sector, Siemens Limited China, Shanghai, China.
J Vasc Interv Radiol. 2014 May;25(5):739-46. doi: 10.1016/j.jvir.2014.01.021.
To prospectively determine the feasibility of flat-detector (FD) computed tomography (CT) perfusion to measure hepatic blood volume (BV) in the angiography suite in patients with hepatocellular carcinoma (HCC).
Twenty patients with HCC were investigated with conventional multislice and FD CT perfusion. CT perfusion was carried out on a multislice CT scanner, and FD CT perfusion was performed on a C-arm angiographic system, before transarterial chemoembolization procedures. BV values of conventional and FD CT perfusion were measured within tumors and liver parenchyma. The arterial perfusion portion of CT perfusion BV was extracted from CT perfusion BV by multiplying it by a hepatic perfusion index. Relative values (RVs) for CT perfusion arterial BV and FD CT perfusion BV (FD BV) were defined by dividing BV of tumor by BV of parenchyma. Relationships between BV and RV values of these two techniques were analyzed.
In all patients, both perfusion procedures were technically successful, and all 33 HCCs larger than 10 mm were identified with both imaging methods. There were strong correlations between the absolute values of FD BV and CT perfusion arterial BV (tumor, r = 0.903; parenchyma, r = 0.920; both P < .001). Bland-Altman analysis showed a mean difference of -0.15 ± 0.24 between RVs for CT perfusion arterial BV and FD BV.
The feasibility of FD CT perfusion to assess BV values of liver tumor and surrounding parenchyma in the angiographic suite was demonstrated.
前瞻性地确定平板探测器（FD）计算机断层扫描（CT）灌注成像在血管造影室测量肝细胞癌（HCC）患者肝血容量（BV）的可行性。
对20例HCC患者进行传统多层螺旋CT和FD CT灌注成像检查。在经动脉化疗栓塞术前，在多层螺旋CT扫描仪上进行CT灌注成像，在C形臂血管造影系统上进行FD CT灌注成像。测量肿瘤内和肝实质的传统CT灌注成像和FD CT灌注成像的BV值。通过将CT灌注BV乘以肝灌注指数，从CT灌注BV中提取CT灌注BV的动脉灌注部分。通过将肿瘤的BV除以实质的BV来定义CT灌注动脉BV和FD CT灌注BV（FD BV）的相对值（RV）。分析这两种技术的BV和RV值之间的关系。
在所有患者中，两种灌注检查在技术上均成功，两种成像方法均识别出所有33个直径大于10 mm的HCC。FD BV和CT灌注动脉BV的绝对值之间存在强相关性（肿瘤，r = 0.903；实质，r = 0.920；均P <.001）。Bland-Altman分析显示，CT灌注动脉BV和FD BV的RV之间的平均差异为-0.15±0.24。
证明了FD CT灌注成像在血管造影室评估肝肿瘤及周围实质BV值的可行性。
