Department of Gynecology, The Affiliated Tumor Hospital, Harbin Medical University, Haping Road 150 of Nangang District, Harbin, Heilongjiang Province, 150081, China.
Department of Internal Medicine, The Affiliated Tumor Hospital, Harbin Medical University, Haping Road 150 of Nangang District, Harbin, Heilongjiang Province, 150081, China.
Hum Pathol. 2014 May;45(5):1031-8. doi: 10.1016/j.humpath.2013.12.020. Epub 2014 Jan 21.
Collagen triple helix repeat containing 1 (CTHRC1) was identified as a novel gene expressed in the adventitia and neointima on arterial injury and was found to be overexpressed in several malignant tumors, such as breast cancer and malignant melanoma. However, the expression of Cthrc1 and its role in gastric cancer progression remain unknown. We investigated the expression of the Cthrc1 protein by immunohistochemistry in 30 normal tissues from the control subjects and 166 gastric carcinomas and analyzed its correlation with various clinicopathological features, including patient outcome. Cthrc1 immunoreactivity was overexpressed in gastric carcinoma cases compared with normal tissues (P < .001). High Cthrc1 expression was found in 108 (65.06%) of these 166 carcinomas and was positively correlated with the American Joint Committee on Cancer stage classification, depth of gastric wall invasion, lymph node metastasis, lymphovascular space involvement, and recurrence but not with age, tumor site, and carcinoembryonic antigen level. Patients with high Cthrc1 expression had significantly poorer overall survival and disease-free survival compared with patients with low expression of Cthrc1 (P = .001 and P = .002, respectively). Multivariate analysis showed that high Cthrc1 expression was an independent prognostic factor for both overall survival and disease-free survival of patients with gastric carcinoma (both P = .005). These results showed that high Cthrc1 expression was associated with progression and prognosis of gastric carcinoma.
胶原蛋白三螺旋重复蛋白 1（CTHRC1）被鉴定为一种在动脉损伤时在外膜和新生内膜中表达的新型基因，并且在几种恶性肿瘤中过表达，如乳腺癌和恶性黑色素瘤。然而，Cthrc1 的表达及其在胃癌进展中的作用尚不清楚。我们通过免疫组织化学法检测了 30 例对照正常组织和 166 例胃癌组织中 Cthrc1 蛋白的表达，并分析了其与各种临床病理特征（包括患者预后）的相关性。与正常组织相比，胃癌病例中 Cthrc1 蛋白的表达升高（P<0.001）。在这些 166 例癌组织中，有 108 例（65.06%）高表达 Cthrc1，且与美国癌症联合委员会分期分类、胃壁浸润深度、淋巴结转移、淋巴管血管间隙浸润及复发呈正相关，而与年龄、肿瘤部位和癌胚抗原水平无关。高 Cthrc1 表达患者的总生存和无病生存均明显低于低 Cthrc1 表达患者（P=0.001 和 P=0.002）。多因素分析显示，高 Cthrc1 表达是胃癌患者总生存和无病生存的独立预后因素（均 P=0.005）。这些结果表明，高 Cthrc1 表达与胃癌的进展和预后相关。
