2型糖尿病患者颈动脉斑块超声组织特征的相关危险因素。

The risk factors associated with ultrasonic tissue characterization of carotid plaque in type 2 diabetic patients.

作者信息

Irie Yoko, Katakami Naoto, Kaneto Hideaki, Takahara Mitsuyoshi, Sakamoto Ken'ya, Kosugi Keisuke, Shimomura Iichiro

机构信息

Department of Metabolic Medicine, Osaka University Graduate School of Medicine.

Department of Metabolic Medicine, Osaka University Graduate School of Medicine; Department of Metabolism and Atherosclerosis, Osaka University Graduate School of Medicine.

出版信息

J Diabetes Complications. 2014 Jul-Aug;28(4):523-7. doi: 10.1016/j.jdiacomp.2014.03.009. Epub 2014 Mar 21.

DOI:10.1016/j.jdiacomp.2014.03.009

PMID:24746439

Abstract

AIMS

Little is known about the related factors of plaque echogenicity in diabetic subjects.

METHODS

This was a single-center, retrospective, study investigating a subgroup of patients of a previously published trial. We enrolled 179 middle-aged and older Japanese type 2 diabetic patients with carotid plaque, and examined the parameters related with echogenicity of carotid plaque evaluated by gray-scale median (GSM).

RESULTS

Proportion of males and body mass index (BMI) were significantly higher and HDL-cholesterol was significantly lower in the patients with low GSM (< 48) plaques (n = 89) as compared to those without it (n = 90). A multiple logistic regression analysis with gender, BMI, and HDL-cholesterol as independent variables and the presence of low GSM plaques as an objective variable showed that male (odds ratio (OR) 2.36, 95%CI 1.05-5.31, p = 0.037) and BMI (OR 1.12 [1.01-1.24], p = 0.029) were independently associated with low GSM plaques. Another multiple logistic regression analysis with gender, BMI, and low-HDL-cholesterolemia (HDL-C < 40 mg/dl) as independent variables showed that low-HDL-cholesterolemia (OR 2.30 [1.03-5.13], p = 0.042) and BMI (OR 1.11 [1.00-1.22], p = 0.046) were independently associated with low GSM plaques.

CONCLUSIONS

Our study suggests that gender, BMI and low-HDL-cholesterol are important determinants of the content of the vascular wall in diabetic subjects.

摘要

目的

关于糖尿病患者斑块回声性的相关因素知之甚少。

方法

这是一项单中心回顾性研究，调查先前发表试验中的一组患者。我们纳入了179例患有颈动脉斑块的中老年日本2型糖尿病患者，并检查了与通过灰度中位数（GSM）评估的颈动脉斑块回声性相关的参数。

结果

与无低GSM（<48）斑块（n = 90）的患者相比，有低GSM斑块（n = 89）的患者中男性比例和体重指数（BMI）显著更高，而高密度脂蛋白胆固醇显著更低。以性别、BMI和高密度脂蛋白胆固醇作为自变量，低GSM斑块的存在作为因变量进行多因素逻辑回归分析显示，男性（比值比（OR）2.36，95%可信区间1.05 - 5.31，p = 0.037）和BMI（OR 1.12 [1.01 - 1.24]，p = 0.029）与低GSM斑块独立相关。另一项以性别、BMI和低高密度脂蛋白血症（高密度脂蛋白胆固醇<40 mg/dl）作为自变量的多因素逻辑回归分析显示，低高密度脂蛋白血症（OR 2.30 [1.03 - 5.13]，p = 0.042）和BMI（OR 1.11 [1.00 - 1.22]，p = 0.046）与低GSM斑块独立相关。