水稻中灵活的 microRNA 臂选择。
Flexible microRNA arm selection in rice.
机构信息
College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China; Institute of Crop Science, Zhejiang Key Laboratory of Crop Germplasm, Zhejiang University, Hangzhou, Zhejiang 310058, China; Zhejiang-California International Nanosystems Institute, Zhejiang University, Hangzhou, Zhejiang 310058, China.
Institute of Crop Science, Zhejiang Key Laboratory of Crop Germplasm, Zhejiang University, Hangzhou, Zhejiang 310058, China.
出版信息
Biochem Biophys Res Commun. 2014 May 9;447(3):526-30. doi: 10.1016/j.bbrc.2014.04.036. Epub 2014 Apr 15.
MicroRNAs act at the post-transcriptional level and guide Argonaute proteins to cleave their corresponding target transcripts. However, little attention has been paid to arm selection in miRNA precursors. In this study, small RNA high-throughput sequencing data from 29 different rice libraries were pooled to investigate tissue- and abiotic stress-specific dynamic expression of miRNAs. We found that more than half of pre-miRNAs showed changes in arm selection in different tissues and/or under different abiotic stresses. Our findings suggest that miRNA selection is remarkably prevalent in plants, providing new insights into the role of miRNAs in plant growth and development.
MicroRNAs 在转录后水平发挥作用，并指导 Argonaute 蛋白切割其相应的靶标转录本。然而，人们对 miRNA 前体中的臂选择关注甚少。在这项研究中，我们汇集了来自 29 个不同水稻文库的高通量小 RNA 测序数据，以研究 miRNA 在不同组织和非生物胁迫下的组织特异性和非生物胁迫特异性动态表达。我们发现，超过一半的前体 miRNA 在不同组织和/或不同非生物胁迫下表现出臂选择的变化。我们的研究结果表明，miRNA 的选择在植物中非常普遍，为 miRNA 在植物生长和发育中的作用提供了新的见解。
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