Sherbourne Cathy D, Stucky Brian D, Edelen Maria Orlando, Eberhart Nicole K, Kleerup Eric, Lara Marielena
RAND Corporation, Santa Monica, Calif.
RAND Corporation, Santa Monica, Calif.
J Allergy Clin Immunol. 2014 Oct;134(4):900-7. doi: 10.1016/j.jaci.2014.03.002. Epub 2014 Apr 18.
In response to recommendations from the 2010 National Institutes of Health Asthma Outcomes Workshop, we developed a system for measuring the negative impact of asthma on quality of life (QoL), which was referred to as the RAND Negative Impact of Asthma on Quality of Life (RAND-IAQL) item bank. The bank contains 65 items that focus on the patient's perception of the impact or bother of asthma on his or her life.
Evidence for the validity of 2 short forms, the RAND-IAQL 4-item and 12-item Short Forms, from the bank is presented.
Using a sample of 2032 adults with asthma, we validated our short forms against the Asthma Quality of Life Questionnaire-Marks (AQLQ-M), the Asthma Control Test, and generic measures of QoL developed by the Patient-reported Outcomes Measurement Information System (PROMIS). Discriminant validity was examined by comparing scores of respondents who differed according to multiple health indicators.
Our sample ranged in age from 18 to 99 years (mean, 43 years), with 14% Hispanic, 11% Asian, 19% African American, and 56% non-Hispanic white race/ethnicity. Men had a significantly worse impact of asthma on QoL than women. The impact of asthma on QoL was greatest in African American and Hispanic subjects compared with that seen in non-Hispanic white subjects. Our measures correlated highly with the AQLQ-M and more strongly with the PROMIS global physical than mental scales. They differentiated between adults with asthma according to their perceived severity, level of control, presence or absence of exacerbations, and physical comorbidity.
The RAND-IAQL item bank, measuring the impact of asthma on QoL, will complement other patient-reported outcomes, such as measures of asthma symptoms, functioning, and control.
为响应2010年美国国立卫生研究院哮喘结局研讨会的建议，我们开发了一种用于测量哮喘对生活质量（QoL）负面影响的系统，即兰德哮喘对生活质量的负面影响（RAND - IAQL）条目库。该条目库包含65个条目，重点关注患者对哮喘对其生活的影响或困扰的感知。
展示该条目库中两种简短形式（RAND - IAQL 4条目和12条目简短形式）有效性的证据。
我们以2032名成年哮喘患者为样本，将我们的简短形式与哮喘生活质量问卷 - 马克斯（AQLQ - M）、哮喘控制测试以及患者报告结局测量信息系统（PROMIS）开发的生活质量通用测量方法进行验证。通过比较根据多种健康指标不同的受访者得分来检验区分效度。
我们的样本年龄范围为18至99岁（平均43岁），其中14%为西班牙裔，11%为亚裔，19%为非裔美国人，56%为非西班牙裔白人种族/族裔。男性哮喘对生活质量的影响明显比女性更严重。与非西班牙裔白人受试者相比，哮喘对生活质量的影响在非裔美国人和西班牙裔受试者中最大。我们的测量方法与AQLQ - M高度相关，与PROMIS总体身体量表的相关性比心理量表更强。它们根据成年人对哮喘严重程度的感知、控制水平、是否有加重情况以及身体合并症对成年哮喘患者进行了区分。
测量哮喘对生活质量影响的RAND - IAQL条目库将补充其他患者报告的结局，如哮喘症状、功能和控制的测量方法。
