Konopacki Jan, Bocian Renata, Kowalczyk Tomasz, Kłos-Wojtczak Paulina
Department of Neurobiology, The University of Lodz, Poland.
Department of Neurobiology, The University of Lodz, Poland.
Brain Res Bull. 2014 Aug;107:1-17. doi: 10.1016/j.brainresbull.2014.04.007. Epub 2014 Apr 18.
Gap junctions (GJs) were discovered more than five decades ago, and since that time enormous strides have been made in understanding their structure and function. Despite the voluminous literature concerning the function of GJs, the involvement of these membrane structures in the central mechanisms underlying oscillations and synchrony in the neuronal network is still a matter of intensive debate. This review summarizes what is known concerning the involvement of GJs as electrical synapses in mechanisms underlying the generation of theta band oscillations. The first part of the chapter discusses the role of GJs in mechanisms of oscillations and synchrony. Following this, in vitro, ex vivo, and in vivo experiments concerning the involvement of GJs in the generation of hippocampal formation theta in rats are reviewed.
间隙连接（GJs）在五十多年前就被发现了，自那时以来，在理解其结构和功能方面取得了巨大进展。尽管有大量关于GJs功能的文献，但这些膜结构在神经网络振荡和同步的核心机制中的作用仍存在激烈争论。本综述总结了关于GJs作为电突触参与θ频段振荡产生机制的已知情况。本章的第一部分讨论了GJs在振荡和同步机制中的作用。在此之后，回顾了关于GJs参与大鼠海马结构θ波产生的体外、离体和体内实验。
