Otto-von-Guericke University, Institute of Psychology II, Magdeburg, Germany; Center for Behavioral Brain Sciences, Magdeburg, Germany.
Otto-von-Guericke University, Institute of Psychology II, Magdeburg, Germany; Center for Behavioral Brain Sciences, Magdeburg, Germany; Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands.
Neurosci Biobehav Rev. 2014 Oct;46 Pt 1:124-38. doi: 10.1016/j.neubiorev.2014.03.024. Epub 2014 Apr 18.
Obsessive-compulsive disorder (OCD) is characterized by overactivity in frontal and striatal brain regions, and event-related potential studies have shown increased brain activity during performance monitoring. The error-related negativity (ERN) is a component of the event-related potential that is observed following incorrect responses, and signals the need for behavioral adjustments. ERN enhancements have even been considered as a biomarker or endophenotype of OCD. However over the past years, enhanced ERN amplitudes, although less reliably, were also found in anxiety and affective disorders. These results question the specificity of ERN alterations to OCD. The present review summarizes current findings on performance monitoring and feedback processing in OCD and their relation to behavioral measures. Further, it discusses possible differential mechanisms contributing to amplitude variations in different clinical conditions.
强迫症（OCD）的特征是额叶和纹状体脑区过度活跃，事件相关电位研究表明，在执行监测任务时大脑活动增加。错误相关负波（ERN）是事件相关电位的一个组成部分，在错误反应后被观察到，信号需要行为调整。ERN 增强甚至被认为是 OCD 的生物标志物或内表型。然而，在过去的几年中，焦虑症和情感障碍也发现了 ERN 振幅增强，尽管不太可靠。这些结果质疑了 ERN 改变对 OCD 的特异性。本综述总结了 OCD 中执行监测和反馈处理的当前研究结果及其与行为测量的关系。此外，还讨论了导致不同临床情况下振幅变化的可能差异机制。
