Suzuki N, Hardebo J E, Kåhrström J, Owman C
Department of Medical Cell Research, University of Lund, Sweden.
Neurosci Lett. 1989 May 22;100(1-3):123-9. doi: 10.1016/0304-3940(89)90671-x.
(GAL)-positive nerve fibers in rat cerebral vessels were demonstrated by immunohistochemistry, and their origin in the trigeminal ganglia and pathway in the nasociliary nerve to the vessels was shown by retrograde tracer technique and nerve transection. Some fibres in the vertebrobasilar system appear to originate in extracranial sources. With the antiserum used only few GAL fibers could be seen in the vessels, mostly in the vertebrobasilar system. In neonatally sympathectomized animals a rich network could be visualized in most pial arteries - still particularly in the vertebrobasilar system - probably as a result of a diminished competition for nerve growth factor. No vasomotor effect of GAL could be detected in isolated segments of pial arteries, neither in normal nor in sympathectomized animals, which rules out a direct postsynaptic effect on vascular tone. GAL did not display prejunctional modulatory action on the adrenergic nerves present in the vascular preparations. A sensory function of GAL is discussed.
通过免疫组织化学方法证实了大鼠脑血管中存在（GAL）阳性神经纤维，通过逆行示踪技术和神经横断术显示了它们起源于三叉神经节以及通过鼻睫神经至血管的路径。椎基底动脉系统中的一些纤维似乎起源于颅外。使用该抗血清时，在血管中仅能看到少数GAL纤维，主要在椎基底动脉系统中。在新生期进行交感神经切除术的动物中，在大多数软脑膜动脉中可看到丰富的网络——尤其是在椎基底动脉系统中——这可能是由于对神经生长因子的竞争减少所致。在软脑膜动脉的离体节段中未检测到GAL的血管运动效应，无论是正常动物还是交感神经切除的动物，这排除了对血管张力的直接突触后效应。GAL对血管制剂中存在的肾上腺素能神经未表现出突触前调节作用。本文讨论了GAL的感觉功能。
