Fallgren B, Ekblad E, Edvinsson L
Department of Zoophysiology, University of Lund, Sweden.
Neurosci Lett. 1989 May 22;100(1-3):71-6. doi: 10.1016/0304-3940(89)90662-9.
The co-localization of substance P (SP) with calcitonin gene-related peptide (CGRP), and vasoactive intestinal peptide (VIP) with neuropeptide Y (NPY) of the guinea pig uterine artery were investigated with immunocytochemistry. The SP/CGRP fibre population was distinct from the VIP/NPY fibre population. Both types of fibres ran in the medial-adventitial border, and appeared as coarsed and fine varicosed. Uterine arterial dilatation was evoked by acetylcholine (ACh), SP, CGRP, and VIP in precontracted arteries as examined by a sensitive in vitro method. Strong relaxations were seen by ACh, CGRP and VIP. NPY had no relaxant effect per se but was found to be a potent inhibitor of vasodilation induced by ACh and SP, while relaxations induced by VIP and CGRP were unaffected. The functional significance of NPY in the uterine artery may to a large extent be to increase tension not only by potentiation of contraction but additionally by inhibiting vasodilator responses.
采用免疫细胞化学方法研究了豚鼠子宫动脉中P物质（SP）与降钙素基因相关肽（CGRP）以及血管活性肠肽（VIP）与神经肽Y（NPY）的共定位情况。SP/CGRP纤维群体与VIP/NPY纤维群体不同。这两种纤维均走行于中膜-外膜边界，呈粗细不等的曲张状。采用灵敏的体外方法检测发现，乙酰胆碱（ACh）、SP、CGRP和VIP均可引起预收缩动脉的子宫动脉扩张。ACh、CGRP和VIP可引起强烈舒张。NPY本身无舒张作用，但发现它是ACh和SP诱导的血管舒张的强效抑制剂，而VIP和CGRP诱导的舒张不受影响。NPY在子宫动脉中的功能意义可能在很大程度上不仅通过增强收缩来增加张力，还通过抑制血管舒张反应来实现。
