André C, d'Auriol L, Lacombe C, Gisselbrecht S, Galibert F
Laboratoire d'Hématologie Expérimentale (UPR 41 CNRS 'Recombinaisons Génétiques'), Hôpital Saint-Louis, Paris, France.
Oncogene. 1989 Aug;4(8):1047-9.
The c-kit proto-oncogene belongs to the tyrosine kinase receptor family. Although its ligand is still unknown, there is increasing evidence to suggest its involvement in hematopoiesis. In order to detect lineage or differentiation related specificity, we have studied c-kit mRNA expression in both human and murine hematopoietic organs and cell lines. We show that c-kit mRNA expression is found at early stages of erythroid and myeloid differentiation. There is however, no evidence of c-kit expression in the lymphoid lineage. Our results suggest a possible role for c-kit as a receptor in the early stages of the erythroid/myeloid differentiation.
c-kit原癌基因属于酪氨酸激酶受体家族。尽管其配体尚不清楚，但越来越多的证据表明它参与造血过程。为了检测谱系或分化相关的特异性，我们研究了人和小鼠造血器官及细胞系中c-kit mRNA的表达。我们发现c-kit mRNA表达存在于红系和髓系分化的早期阶段。然而，没有证据表明c-kit在淋巴谱系中表达。我们的结果提示c-kit可能作为红系/髓系分化早期阶段的一种受体发挥作用。
