Raymond W A, Leong A S
Division of Tissue Pathology, Institute of Medical and Veterinary Science, Adelaide.
Pathology. 1989 Jan;21(1):11-5. doi: 10.3109/00313028909059522.
Axillary lymph node involvement by tumour metastasis is of major prognostic significance in breast carcinoma. In an immunocytochemical study using monoclonal antibodies to cytokeratins, 7 (23%) of 30 cases of node-negative breast carcinoma were found to contain metastases, resulting in upstaging of the disease. The metastatic foci were missed on routine screening of H&E stained sections. There was no significant association between the presence of metastases and the location, diameter, type or grade of the primary tumour. These findings emphasize the contribution of immunocytochemical staining for the identification and detection of metastatic breast carcinoma in axillary lymph nodes.
肿瘤转移导致腋窝淋巴结受累对乳腺癌的预后具有重要意义。在一项使用抗细胞角蛋白单克隆抗体的免疫细胞化学研究中，30例腋窝淋巴结阴性的乳腺癌患者中有7例（23%）发现存在转移，从而导致疾病分期上调。在苏木精-伊红（H&E）染色切片的常规筛查中遗漏了转移灶。转移灶的存在与原发肿瘤的位置、直径、类型或分级之间无显著关联。这些发现强调了免疫细胞化学染色在识别和检测腋窝淋巴结转移性乳腺癌中的作用。
