University Eye Department, University Hospital Centre Osijek, Osijek, Croatia.
Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.
BMC Ophthalmol. 2021 Oct 5;21(1):354. doi: 10.1186/s12886-021-02122-y.
The purpose of this cross-sectional study involving healthy emmetropic four-year-old Caucasian children was to provide a macular perfusion normative database acquired with optical coherence tomography angiography (OCTA). One eye of each examinee underwent OCTA imaging. The following parameters were analyzed using AngioTool Image J software: vessels area (VA), vessels density (VD), total number of junctions (TNJ), junctions density (JD), total vessel length (TVL), average vessel length (AVL), total number of endpoints (TNEP), lacunarity (L), vessel diameter index (VDI), tortuosity (T) and foveal avascular zone (FAZ). Average central macular thickness (CMT) and average central macular volume (CMV) were measured.
Sixty-two eyes of 62 children of average age 50.4 ± 3.8 months were examined. VA, VD, and T increased from the inner towards the outer layers of the retina. The intermediate capillary plexus had the highest JD and TNEP and narrowest FAZ. Retinal sexual differentiation was supported with higher values of the retinal VA, VDI and TNEP, and chorioretinal VA, VDI and L in males. The choriocapillaris presented with the highest VD, AVL, and T and the lowest L and TNEP.
The study provides the first detailed normative database of the macular vascular network in the youngest uniform cohort of emmetropic four-year-old children.
本横断面研究涉及健康的正视白人四岁儿童，旨在提供使用光学相干断层扫描血管造影术（OCTA）获得的黄斑灌注正常数据库。每位受检者的一只眼接受 OCTA 成像。使用 AngioTool Image J 软件分析以下参数：血管面积（VA）、血管密度（VD）、总节点数（TNJ）、节密度（JD）、总血管长度（TVL）、平均血管长度（AVL）、总端点数（TNEP）、空洞度（L）、血管直径指数（VDI）、扭曲度（T）和无血管区（FAZ）。测量平均中央黄斑厚度（CMT）和平均中央黄斑体积（CMV）。
共检查了 62 名平均年龄为 50.4±3.8 个月的儿童的 62 只眼。VA、VD 和 T 从视网膜内层向外层增加。中间毛细血管丛具有最高的 JD 和 TNEP 以及最窄的 FAZ。视网膜性别分化表现为男性视网膜 VA、VDI 和 TNEP 以及脉络膜视网膜 VA、VDI 和 L 较高。脉络丛具有最高的 VD、AVL 和 T 以及最低的 L 和 TNEP。
本研究首次提供了最年轻的正视四岁儿童黄斑血管网络的详细正常数据库。
