Han Ling, Wang Yingxiao, Gan Yonghua, Xu Lijun
Department of Respiration, Jilin University 1st Hospital, No. 71, Xinmin Road, Changchun, 130021, Jilin, China.
Cell Biochem Biophys. 2014 Sep;70(1):481-4. doi: 10.1007/s12013-014-9944-1.
The objective of the study was to investigate the effects of adaptive support ventilation (ASV) and synchronized intermittent mandatory ventilation (SIMV) on peripheral circulation of chronic obstructive pulmonary disease (COPD) patients with respiratory failure. 86 COPD patients with respiratory failure were recruited in this study. Self-control method was used to compare the effect of ASV and SIMV on the parameters of ventilation machine, heart rate, blood pressure, central venous pressure (CVP), and blood gas markers. When the patients in ASV and SIMV groups were compared, respiratory rate, tidal volume, and peak airway pressure (PIP) showed significant difference. When minute ventilation (MV) was compared, no significant difference was shown. When peripheral circulation parameters were compared, peripheral circulation heart rate, SBP, DBP, and CVP showed significant difference. Compared with SIMV group, PaO2, pH, and SaO2 values were remarkably increased (P < 0.01) while no significant difference was found for partial pressure of carbon dioxide (pCO2) when two groups were compared. In conclusion, when mechanical ventilation was used in COPD patients with respiratory failure, ASV can significantly improve clinical outcomes.
本研究的目的是探讨适应性支持通气（ASV）和同步间歇指令通气（SIMV）对慢性阻塞性肺疾病（COPD）呼吸衰竭患者外周循环的影响。本研究招募了86例COPD呼吸衰竭患者。采用自身对照法比较ASV和SIMV对呼吸机参数、心率、血压、中心静脉压（CVP）和血气指标的影响。比较ASV组和SIMV组患者时，呼吸频率、潮气量和气道峰压（PIP）有显著差异。比较分钟通气量（MV）时，未显示出显著差异。比较外周循环参数时，外周循环心率、收缩压、舒张压和CVP有显著差异。与SIMV组相比，两组比较时，动脉血氧分压（PaO2）、pH值和动脉血氧饱和度（SaO2）值显著升高（P<0.01），而二氧化碳分压（pCO2）无显著差异。总之，当对COPD呼吸衰竭患者使用机械通气时，ASV可显著改善临床结局。
