Olsen O, Ainsworth M, Schaffalitzky de Muckadell O B, Cantor P
Dept. of Surgical Gastroenterology C, Rigshospitalet, Copenhagen, Denmark.
Scand J Gastroenterol. 1989 Jun;24(5):529-32. doi: 10.3109/00365528909093084.
To evaluate the importance of the terminal carboxy group of the oleic acid molecule in the release of secretin and cholecystokinin (CCK) to plasma, six normal persons were stimulated twice with duodenal perfusates containing either 20 mM oleic acid or 20 mM oleyl alcohol. Oleic acid increased the pancreatic secretion of bicarbonate and amylase and the concentrations of secretin and CCK in plasma and provoked gallbladder emptying. Oleyl alcohol only increased the amylase output slightly, but significantly. It is concluded that the carboxy group of the fat molecule has an important role in triggering the release of secretin and CCK to plasma.
为评估油酸分子的末端羧基在促胰液素和胆囊收缩素（CCK）释放至血浆过程中的重要性，对6名正常人分别用含20 mM油酸或20 mM油醇的十二指肠灌注液进行了两次刺激。油酸增加了胰腺碳酸氢盐和淀粉酶的分泌以及血浆中促胰液素和CCK的浓度，并引起胆囊排空。油醇仅轻微但显著地增加了淀粉酶的分泌量。结论是脂肪分子的羧基在触发促胰液素和CCK释放至血浆中起重要作用。
