Olsen O, Schaffalitzky de Muckadell O B, Cantor P
Surgical Dept. C, Rigshospitalet, Copenhagen, Denmark.
Scand J Gastroenterol. 1987 Nov;22(9):1109-14. doi: 10.3109/00365528708991967.
In 20 normal persons we investigated the effects of duodenal osmolality on the release of secretin and cholecystokinin (CCK), pancreaticobiliary secretion, and fat absorption after intestinal infusion of emulsified oleic acid (pH 6.0). The release of CCK was found to be unaffected by the changes in osmolality, whereas the plasma levels of secretin were affected in parallel with volume and bicarbonate secretion. An inverse relation was found between fatty acid absorption and release of secretin and bicarbonate secretion but not between fatty acid absorption and release of CCK. It is suggested that the secretin and CCK cells respond differently to emulsified oleic acid.
在20名正常人中，我们研究了十二指肠渗透压对分泌素和胆囊收缩素（CCK）释放、胰胆分泌以及乳化油酸（pH 6.0）肠道输注后脂肪吸收的影响。发现CCK的释放不受渗透压变化的影响，而分泌素的血浆水平与容量和碳酸氢盐分泌呈平行变化。脂肪酸吸收与分泌素释放和碳酸氢盐分泌之间呈负相关，但与CCK释放无关。提示分泌素细胞和CCK细胞对乳化油酸的反应不同。
