Sharma Veena, Singh Manu
Department of Bioscience and Biotechnology, Banasthali University, Banasthali, Rajasthan, India.
Toxicol Int. 2014 Jan;21(1):29-36. doi: 10.4103/0971-6580.128789.
Enormous propensity of plants to synthesize a variety of structurally diverse bioactive compounds, has made the plant kingdom a potential source of chemical constituents with various therapeutic values, including antitumor and cytotoxic activities. Blood is a good indicator to determine the physiological and pathological status of man and animal. The objective of the present study is to determine the effect of Operculina turpethum root extract and its isolated glycoside treatment on the hematological parameters in the mice with N-Nitrosodimethylamine (NDMA) induced cancer.
The body weights of the animals were recorded before and after the experiment. Non-coagulated blood was tested for total erythrocyte count, total leukocyte count, hemoglobin, differential leukocyte count (DLC) and for other blood indices.
A significant (P < 0.01), (P < 0.001) recovery of the red blood cell and white blood cell counts, packed cell volume and hemoglobin content in the host after 21 day treatment was shown.
These results show that the extract of Operculina turpethum is relatively safe following oral administration and have possible stimulatory effect on red blood cell production and there was dose dependent therapeutic effect.
植物具有合成多种结构各异的生物活性化合物的巨大倾向，这使得植物界成为具有各种治疗价值的化学成分的潜在来源，包括抗肿瘤和细胞毒性活性。血液是确定人和动物生理及病理状态的良好指标。本研究的目的是确定盒果藤根提取物及其分离出的糖苷处理对N-亚硝基二甲胺（NDMA）诱导的癌症小鼠血液学参数的影响。
在实验前后记录动物的体重。对未凝固的血液进行全红细胞计数、全白细胞计数、血红蛋白、白细胞分类计数（DLC）及其他血液指标检测。
经过21天的治疗后，宿主的红细胞和白细胞计数、血细胞比容和血红蛋白含量有显著（P < 0.01）、（P < 0.001）恢复。
这些结果表明，盒果藤提取物口服相对安全，对红细胞生成可能有刺激作用，且具有剂量依赖性治疗效果。
