Aceti A, Celestino D, Caferro M, Pennica A, Sebastiani A
Institute of the Clinic of Tropical and Infectious Diseases, La Sapienza University, Rome, Italy.
Trop Geogr Med. 1989 Apr;41(2):151-3.
Total and specific IgE antibodies were determined in 20 patients with invasive amoebiasis. Using a histamine release assay by passive sensitized human leukocytes, a significant increase of Entamoeba histolytica induced IgE-mediated histamine liberation was found in basophils sensitized with sera from patients with amoebiasis as compared to those of control groups. Concerning the total serum IgE, no statistically significant changes were found in different serum groups. Our results suggest that E. histolytica can induce a detectable level of circulating specific IgE without change in total serum IgE.
在20例侵袭性阿米巴病患者中测定了总IgE抗体和特异性IgE抗体。通过被动致敏人白细胞组胺释放试验发现，与对照组相比，用阿米巴病患者血清致敏的嗜碱性粒细胞中，溶组织内阿米巴诱导的IgE介导的组胺释放显著增加。关于血清总IgE，不同血清组未发现有统计学意义的变化。我们的结果表明，溶组织内阿米巴可诱导可检测水平的循环特异性IgE，而血清总IgE无变化。
