Malinovskaia V V, Murzabaeva R T, Manakhova L S, Mironova L L
Vopr Virusol. 1989 Mar-Apr;34(2):180-3.
In clinical trials in 24 healthy volunteers of different doses of reaferon inoculated intramuscularly and intravenously for 3 days a pyrogenic reaction was observed the intensity of which depended upon the dose and route of inoculation. Reaferon exerted a dose-dependent effect on the recipient's interferon system: with large doses the interferon response of leukocytes and the capacity of lymphocytes for gamma-IF synthesis were markedly inhibited, whereas low doses (2 million IU/day) caused no significant changes. The intravenous inoculation of reaferon produced a relatively high but short-term, and the intramuscular inoculation a relatively low but of longer duration antiviral activity in the blood serum.
在24名健康志愿者身上进行的临床试验中，分别以不同剂量的重组干扰素进行肌内和静脉注射，持续3天，观察到有发热反应，其强度取决于接种剂量和途径。重组干扰素对受试者的干扰素系统产生剂量依赖性作用：大剂量时，白细胞的干扰素反应和淋巴细胞合成γ-干扰素的能力受到明显抑制，而低剂量（200万国际单位/天）则未引起显著变化。静脉注射重组干扰素在血清中产生相对较高但持续时间较短的抗病毒活性，而肌内注射产生相对较低但持续时间较长的抗病毒活性。
