Gabrilovich D I, Serebrovskaia L V, Murzabaeva R T, Semashko M I, Zmyzgova A V
Zh Mikrobiol Epidemiol Immunobiol. 1988 Mar(3):61-5.
The administration of Reaferon, the analog of human alpha 2-interferon obtained by means of gene engineering technigues, to 25 volunteers revealed the ability of small doses of this preparation to produce a stimulating effect on the capacity of lymphocytes and neutrophils for rosette formation. When introduced in large doses, the preparation sharply suppressed this capacity. A significant decrease in the T- and B-lymphocyte count, as well as in the neutrophil count, was noted. These changes persisted for 7 days after the course of Reaferon injections had been over. The intravenous injection of the preparation produced more pronounced effect than its intramuscular injection in the same doses. No essential changes in the count of the precursor cells of both T- and B-lymphocytes were registered.
对25名志愿者施用通过基因工程技术获得的人α2干扰素类似物Reaferon，结果显示小剂量的该制剂能够对淋巴细胞和中性粒细胞形成玫瑰花结的能力产生刺激作用。当大剂量使用时，该制剂会显著抑制这种能力。观察到T淋巴细胞和B淋巴细胞计数以及中性粒细胞计数显著下降。在Reaferon注射疗程结束后，这些变化持续了7天。相同剂量下，该制剂静脉注射产生的效果比肌肉注射更明显。T淋巴细胞和B淋巴细胞前体细胞计数均未出现实质性变化。
