Guo Huishi
J Nanosci Nanotechnol. 2014 Feb;14(2):1884-97. doi: 10.1166/jnn.2014.9191.
Chiral analysis is one of the most important/challenging analytical tasks due to the necessity for differentiation of very slight differences in the molecular configurations between chiral isomers. It consists of two processes, chiral recognition and signal transduction. Quartz crystal microbalance (QCM) holds a great promise for the next-generation sensors, due to its remarkable mass sensitivity, fast response, capable of online detection and low cost. It has been the focus of academic and practical research on chiral analysis during the last two decades. This review provides a detailed overview of recent advances made in chiral analysis based on QCM detection with regard to the recognition elements, which include synthetic macromolecules, molecular imprinting polymers (MIPs), proteins, amino acids and their derivatives, etc. The prospects of using QCM for chiral analysis are also put forward.
由于需要区分手性异构体之间分子构型的微小差异，手性分析是最重要/最具挑战性的分析任务之一。它包括两个过程，即手性识别和信号转导。石英晶体微天平（QCM）因其卓越的质量灵敏度、快速响应、能够在线检测以及低成本，在下一代传感器方面具有巨大潜力。在过去二十年中，它一直是手性分析学术和实际研究的重点。本综述详细概述了基于QCM检测在手性分析方面取得的最新进展，涉及识别元件，包括合成大分子、分子印迹聚合物（MIP）、蛋白质、氨基酸及其衍生物等。还提出了将QCM用于手性分析的前景。
