结膜角化，一种对眼部β受体阻滞剂的异常反应。
Conjunctival keratinisation, an abnormal reaction to an ocular beta-blocker.
作者信息
Derous D, de Keizer R J, de Wolff-Rouendaal D, Soudijn W
机构信息
Department of Ophthalmology, University Hospital, Leiden, The Netherlands.
出版信息
Acta Ophthalmol (Copenh). 1989 Jun;67(3):333-8. doi: 10.1111/j.1755-3768.1989.tb01883.x.
Abstract
Conjunctival leucoplakia was induced by the local beta-blocker metipranolol in one case. Withdrawal of the drug and application of all-trans retinoic acid ointment resulted in resolving of the keratinisation. A striking pharmacological resemblance is discovered between metipranolol and practolol. Metipranolol seems to be a less toxic phenol derivative of practolol. Nevertheless, it seems able to act as antigen.
摘要
1例局部使用β受体阻滞剂美替洛尔诱发了结膜白斑。停用该药物并应用全反式维甲酸软膏后，角化现象消退。发现美替洛尔与心得宁在药理学上有显著相似之处。美替洛尔似乎是心得宁毒性较小的酚类衍生物。然而，它似乎能够作为抗原起作用。
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