Le Jeunne C, Munera Y, Teillet L, Hugues F C
Laboratoire de Thérapeutique Appliquée, Hôpital Laennec, Paris.
Allerg Immunol (Paris). 1988 Sep;20(7):267-9.
Effects of three beta antagonist eye drops are studied in three parallel groups of asthmatic patients. Each ocular topic lowers FEV1 with a maximal effect of -13.4 +/- 2.1% for timolol (n = 15), -17.9 +/- 3.3% for metipranolol (n = 10), and -8.6 +/- 3.0% for carteolol (n = 10). Vital capacity, systolic and diastolic pressure scarcely change, but all three eye drops give a dose dependent sinus bradycardia. Intravenous infusion of isoproterenol (exclusive beta agonist) shows an important inhibition of cardiac receptors by timolol. Doses necessary to increase heart rate of 50% are of 0.242 +/- 0.019 microgram/kg before eye drops are instilled and of 0.647 +/- 0.054 microgram/kg after timolol treatment. This study stresses out the necessity of following recommended doses and respecting carefully classical contra indications of beta blocking agents and specially asthma.
在三组平行的哮喘患者中研究了三种β受体拮抗剂眼药水的效果。每种眼药水滴眼后均降低了第一秒用力呼气量（FEV1），噻吗洛尔（n = 15）的最大降幅为-13.4 +/- 2.1%，美替洛尔（n = 10）为-17.9 +/- 3.3%，卡替洛尔（n = 10）为-8.6 +/- 3.0%。肺活量、收缩压和舒张压几乎没有变化，但所有三种眼药水均引起剂量依赖性窦性心动过缓。静脉注射异丙肾上腺素（纯β受体激动剂）显示噻吗洛尔对心脏受体有重要抑制作用。滴眼药前使心率增加50%所需的剂量为0.242 +/- 0.019微克/千克，噻吗洛尔治疗后为0.647 +/- 0.054微克/千克。本研究强调了遵循推荐剂量以及严格遵守β受体阻滞剂尤其是哮喘患者的经典禁忌证的必要性。
