Gongwer M A, Murphy J M, McBride W J, Lumeng L, Li T K
Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis.
Alcohol. 1989 Jul-Aug;6(4):317-20. doi: 10.1016/0741-8329(89)90089-x.
The contents of dopamine (DA), serotonin (5-HT) and their primary acid metabolites were assayed in ten brain regions of the selectively bred high-alcohol drinking (HAD) and low-alcohol drinking (LAD) lines of rats. Compared with the LAD line, the contents of 5-HT and/or 5-hydroxyindoleacetic acid were approximately 10-20% (p less than 0.05) lower in several brain regions of the HAD line (cerebral cortex, striatum, nucleus accumbens, septal nuclei, hippocampus and hypothalamus). The levels of DA, 3,4-dihydroxyphenylacetic acid and homovanillic acid were also 10-20% lower in the nucleus accumbens and anterior striatum (p less than 0.05) of the HAD animals. These data are in agreement with previous findings that comparatively lower levels in 5-HT and DA systems are associated with high-alcohol drinking in rodents and support the involvement of certain 5-HT and DA pathways in the mediation of alcohol drinking behavior.
在选择性培育的高饮酒量（HAD）和低饮酒量（LAD）品系大鼠的十个脑区中，检测了多巴胺（DA）、5-羟色胺（5-HT）及其主要酸性代谢产物的含量。与LAD品系相比，HAD品系大鼠的几个脑区（大脑皮层、纹状体、伏隔核、隔核、海马体和下丘脑）中5-HT和/或5-羟吲哚乙酸的含量大约低10%-20%（p<0.05）。HAD大鼠伏隔核和前纹状体中的DA、3,4-二羟基苯乙酸和高香草酸水平也低10%-20%（p<0.05）。这些数据与之前的研究结果一致，即5-HT和DA系统中相对较低的水平与啮齿动物的高饮酒量有关，并支持某些5-HT和DA通路参与酒精饮用行为的调节。
