Wang Frances L, Chassin Laurie
Department of Psychology, Arizona State University.
Department of Psychiatry, University of Pittsburgh Medical Center.
Clin Psychol Sci. 2018;6(1):106-122. doi: 10.1177/2167702617733817. Epub 2017 Oct 6.
Serotonin (5-HT) functioning is associated with alcohol problems. However, the mechanisms underlying this association remain unclear. The current study tested whether five separate dimensions of impulsivity (UPPS-P) mediated the relation between a polygenic score indexing 5-HT functioning and alcohol problems and whether any of these paths were moderated by age. Results showed that a 5-HT polygenic score predicted alcohol problems indirectly through negative urgency, but not any other facet of impulsivity. The 5-HT polygenic score also directly predicted alcohol problems. No age moderation was found. Findings suggest that negative urgency might be one important mechanism underlying the relation between genetically-influenced 5-HT functioning and alcohol problems. However, genetically-influenced 5-HT functioning likely influences alcohol problems through additional mechanisms. More broadly, results suggest that the previously observed transdiagnostic nature of 5-HT functioning on diverse types of psychopathology might be, in part, explained by its effect on negative urgency.
血清素（5-羟色胺，5-HT）功能与酒精问题相关。然而，这种关联背后的机制仍不清楚。本研究测试了冲动性的五个独立维度（UPPS-P）是否介导了索引5-HT功能的多基因评分与酒精问题之间的关系，以及这些路径是否受到年龄的调节。结果显示，5-HT多基因评分通过消极紧迫性间接预测酒精问题，但不是通过冲动性的任何其他方面。5-HT多基因评分也直接预测酒精问题。未发现年龄调节作用。研究结果表明，消极紧迫性可能是遗传影响的5-HT功能与酒精问题之间关系的一个重要机制。然而，遗传影响的5-HT功能可能通过其他机制影响酒精问题。更广泛地说，研究结果表明，先前观察到的5-HT功能在不同类型精神病理学上的跨诊断性质，可能部分是由其对消极紧迫性的影响所解释的。
