Barer G R, Emery C J, Mohammed F H, Mungall I P
Q J Exp Physiol Cogn Med Sci. 1978 Apr;63(2):157-69. doi: 10.1113/expphysiol.1978.sp002428.
Pulmonary vasomotor actions of histamine and the possible relationship of histamine to hypoxic pulmonary vasconstriction were studied in anaesthetized cats with one lobe of lung perfused at constant flow and in isolated perfused rat and ferret lungs. In the cat histamine caused dilatation, biphasic responses and constriction with increasing doses. Histamine induced dilatation was better demonstrated during hypoxic vasoconstriction and was reduced by an H2 histamine antagonist; constriction with histamine was abolished by an H1 antagonist. Histamine also caused both vasodilatation and vasoconstriction in ferret lungs. A mast cell stabilizing agent had no effect on hypoxic pulmonary vasoconstriction in cats or rats. This response was unaffected in cats but greatly reduced in rats and ferrets by cyproheptadine, a combined histamine and 5-hydroxy-tryptamine inhibitor. It was unaffected in cats but abolished in ferrets an H1 histamine inhibitor. It was again unaffected in cats but greatly reduced in rats and ferrets by an H2 histamine inhibitor. These species differences may reflect differences in mechanism but more probably reflect non-specific effects of the inhibitors in certain circumstances. However, when drugs nearly abolished hypoxic vasoconstriction, ATP still caused vasoconstriction.
在麻醉猫身上，通过恒流灌注单叶肺进行研究，同时也在离体灌注的大鼠和雪貂肺中，研究了组胺的肺血管运动作用以及组胺与低氧性肺血管收缩的可能关系。在猫身上，随着剂量增加，组胺引起扩张、双相反应和收缩。组胺诱导的扩张在低氧性血管收缩期间表现得更明显，并且可被组胺H2拮抗剂减弱；组胺引起的收缩可被H1拮抗剂消除。组胺在雪貂肺中也引起血管舒张和收缩。肥大细胞稳定剂对猫或大鼠中的低氧性肺血管收缩没有影响。这种反应在猫中不受影响，但在大鼠和雪貂中，组胺和5-羟色胺联合抑制剂赛庚啶可使其大大减弱。在猫中不受影响，但在雪貂中，组胺H1抑制剂可将其消除。在猫中再次不受影响，但在大鼠和雪貂中，组胺H2抑制剂可使其大大减弱。这些物种差异可能反映了机制上的差异，但更可能反映了抑制剂在某些情况下的非特异性作用。然而，当药物几乎消除低氧性血管收缩时，ATP仍会引起血管收缩。
