催产素拮抗剂在反复种植失败中的作用。
The role of oxytocin antagonists in repeated implantation -failure.
作者信息
Decleer W, Osmanagaoglu K, Devroey P
机构信息
IVF Centrum, AZ Jan Palfijn, Henri Dunantlaan 5, 9000 Gent, Belgium.
IVF Centrum, AZ Jan Palfijn, Henri Dunantlaan 5, 9000 Gent, Belgium ; Center of Reproductive Medicine, Dutch- Speaking Free University Brussels, Laarbeeklaan 101,1090 Brussels, Belgium.
出版信息
Facts Views Vis Obgyn. 2012;4(4):227-9.
A prospective cohort study has been performed to find out if the administration of an oxytocin antagonist (Atosiban) at the occasion of embryo transfer has an effect on the pregnancy rate in patients with repeated failure of implantation. A total of 52 women with repeated failure of implantation after IVF/ICSI were included in this study. The ongoing pregnancy rate (OPR) in the total group of patients was 12 out of 52 (23.1%). Based on embryo quality all cases were categorized in two groups. One with good embryo quality (Group A) and one with poor quality embryos (Group B). Of all patients who became pregnant, 11 belonged to the group of 26 patients with good quality embryos (OPR 42.3 %) and only one to the group of 26 patients with poor quality embryos (OPR 3.8 %). Our results indicate that when good quality embryos can be obtained, the use of Atosiban at the occasion of embryo transfer might offer a significant better implantation rate in women with repeated implantation failure after IVF/ICSI.
已开展一项前瞻性队列研究，以确定在胚胎移植时给予催产素拮抗剂（阿托西班）是否会对反复种植失败患者的妊娠率产生影响。本研究共纳入52例IVF/ICSI后反复种植失败的女性。患者总数中的持续妊娠率（OPR）为52例中的12例（23.1%）。根据胚胎质量，所有病例分为两组。一组胚胎质量良好（A组），另一组胚胎质量较差（B组）。在所有怀孕的患者中，11例属于26例胚胎质量良好的患者组（OPR 42.3%），只有1例属于26例胚胎质量较差的患者组（OPR 3.8%）。我们的结果表明，当能够获得质量良好的胚胎时，在胚胎移植时使用阿托西班可能会使IVF/ICSI后反复种植失败的女性的着床率显著提高。
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