de Boer Marrit K, Castelein Stynke, Wiersma Durk, Schoevers Robert A, Knegtering Henderikus
a Department of Psychiatry , University Medical Center Groningen, University of Groningen.
J Sex Res. 2014;51(4):383-9. doi: 10.1080/00224499.2013.865111.
Sexual dysfunction is a frequent side effect of antipsychotics, but information is scant regarding the psychometric properties and clinical usefulness of currently existing questionnaires. This systematic review compares the psychometric properties and content of questionnaires for assessment of sexual functioning in patients using antipsychotics. A systematic literature search was performed using three electronic databases (PubMed, Embase, and PsycINFO) with predefined search terms. We identified six validated instruments for assessment of sexual functioning in patients using antipsychotics: the Antipsychotic Non-Neurological Side Effects Rating Scale (ANNSERS), the Arizona Sexual Experience Scale (ASEX), the Antipsychotics and Sexual Functioning Questionnaire (ASFQ), the Changes in Sexual Function Questionnaire-14 (CSFQ-14), the Nagoya Sexual Function Questionnaire (NSFQ), and the Psychotropic-Related Sexual Dysfunction Questionnaire (PRSexDQ). The ASFQ, CSFQ-14, and PRSexDQ cover all stages of sexual functioning, which makes these questionnaires preferable to the other three questionnaires described. The ASFQ and PRSexDQ are clinician-administered and ask for a change in sexual functioning related to medication. The ASFQ assesses improvement as well as deterioration of sexual functioning, and includes items about hyperprolactinemia. The CSFQ-14 is useful when self-report is desired but contains more items.
性功能障碍是抗精神病药物常见的副作用，但关于现有问卷的心理测量特性和临床实用性的信息却很少。本系统评价比较了用于评估使用抗精神病药物患者性功能的问卷的心理测量特性和内容。使用三个电子数据库（PubMed、Embase和PsycINFO），采用预定义的检索词进行了系统的文献检索。我们确定了六种用于评估使用抗精神病药物患者性功能的有效工具：抗精神病非神经副作用评定量表（ANNSERS）、亚利桑那性体验量表（ASEX）、抗精神病药物与性功能问卷（ASFQ）、性功能问卷-14变化量表（CSFQ-14）、名古屋性功能问卷（NSFQ）和精神药物相关性性功能障碍问卷（PRSexDQ）。ASFQ、CSFQ-14和PRSexDQ涵盖了性功能的所有阶段，这使得这些问卷比所描述的其他三种问卷更具优势。ASFQ和PRSexDQ由临床医生管理，并询问与药物相关的性功能变化。ASFQ评估性功能的改善以及恶化情况，并包括有关高催乳素血症的项目。当需要自我报告时，CSFQ-14很有用，但包含的项目更多。
