Mayson E, Saverimuttu J, Cartwright K
Haematology Department, Wollongong Hospital, Wollongong, New South Wales, Australia.
Intern Med J. 2014 Apr;44(4):417-22. doi: 10.1111/imj.12390.
Follicular lymphomas are the most common of the clinically indolent non-Hodgkin lymphomas. The immunophenotypic pattern of follicular lymphoma classically demonstrates the B-cell markers CD19, CD20, CD22, CD79a, surface immunoglobulin and CD10. The tumour cells are usually negative for CD5. We described two cases of CD5-positive follicular lymphoma. This finding has rarely been described. Our aim was to discuss two cases of CD5-positive follicular lymphoma and review the published literature on the significance of CD5 expression. Bone marrow biopsies showing involvement with follicular lymphoma at our institution over the past 34 months were evaluated for the presence of CD5 positivity by flow cytometry and immunohistochemistry. Two of eight cases (25%) of the follicular lymphomas with marrow involvement at our institution were found to be CD5-positive. Only 36 cases of CD5-positive follicular lymphoma have previously been described in the literature. The clinical and therapeutic significance of this remains uncertain. More research into such cases may establish whether the presence of this aberrant marker bears prognostic significance.
滤泡性淋巴瘤是临床上最常见的惰性非霍奇金淋巴瘤。滤泡性淋巴瘤的免疫表型模式经典地显示B细胞标志物CD19、CD20、CD22、CD79a、表面免疫球蛋白和CD10。肿瘤细胞通常CD5呈阴性。我们描述了两例CD5阳性的滤泡性淋巴瘤。这一发现很少被描述。我们的目的是讨论两例CD5阳性的滤泡性淋巴瘤，并回顾已发表的关于CD5表达意义的文献。对过去34个月内在我们机构进行的显示有滤泡性淋巴瘤累及的骨髓活检标本，通过流式细胞术和免疫组织化学评估CD5阳性情况。在我们机构的8例有骨髓累及的滤泡性淋巴瘤病例中，有2例（25%）被发现为CD5阳性。此前文献中仅描述过36例CD5阳性的滤泡性淋巴瘤。其临床和治疗意义仍不确定。对此类病例进行更多研究可能会确定这种异常标志物的存在是否具有预后意义。
