Section of Dermatology, Dipartimento di Scienze della Salute (DISSAL), University of Genoa and S. Martino University Hospital, Genoa, Italy.
Am J Clin Dermatol. 2014 Aug;15(4):371-7. doi: 10.1007/s40257-014-0074-8.
The pathogenesis of psoriasis is complex, with a significant role suggested for pro-inflammatory mediators. There is strong evidence of an association between psoriasis and the metabolic syndrome (MetS), a cluster of cardiovascular risk factors, which impose a substantial disease burden.
This study aimed to evaluate the prevalence of MetS and to examine the implications of disease severity, type 2 diabetes mellitus, and cardiovascular disease in a large cohort of Italian psoriatic patients representative of the whole population.
This was a cross-sectional study involving 13 dermatological clinics in Italy. The primary study endpoint was a comparison of the prevalence of MetS between psoriatic patients and a non-psoriatic control group; secondary endpoints included the influence of psoriasis severity on the prevalence of MetS, and the relative prevalence and risk of type 2 diabetes mellitus and cardiovascular disorders.
A total of 720 patients were enrolled (n = 360 per group). The prevalence of MetS was 26.84% in the psoriatic population and 15.16% in the control population (p = 0.0001; adjusted odds ratio 1.96). MetS was associated with a greater degree of psoriasis severity, and the prevalence and risk of diabetes tended to be higher in psoriatic patients than in the control group.
In the Italian population, the prevalence of MetS and associated comorbidities is elevated in patients with psoriasis compared with non-psoriatic subjects, as has been demonstrated in other countries. Our findings reinforce the importance of considering the implications of metabolic comorbidities in treating patients with psoriasis.
银屑病的发病机制复杂，促炎介质起重要作用。有强有力的证据表明银屑病与代谢综合征（MetS）有关，代谢综合征是一组心血管危险因素，会给患者带来沉重的疾病负担。
本研究旨在评估意大利一个大型银屑病队列人群中代谢综合征的患病率，并探讨疾病严重程度、2 型糖尿病和心血管疾病的影响。
这是一项在意大利 13 家皮肤科诊所进行的横断面研究。主要研究终点是比较银屑病患者和非银屑病对照组之间代谢综合征的患病率；次要终点包括银屑病严重程度对代谢综合征患病率的影响，以及 2 型糖尿病和心血管疾病的相对患病率和风险。
共纳入 720 例患者（每组 360 例）。银屑病患者中代谢综合征的患病率为 26.84%，对照组为 15.16%（p = 0.0001；调整后的优势比 1.96）。代谢综合征与银屑病严重程度呈正相关，且银屑病患者的糖尿病患病率和风险均高于对照组。
在意大利人群中，与非银屑病患者相比，银屑病患者的代谢综合征患病率和相关合并症更高，这与其他国家的研究结果一致。我们的研究结果强调了在治疗银屑病患者时需要考虑代谢合并症影响的重要性。
