Descamps Vincent, Mahé Emmanuel, Maccari François, Begon Edouard, Barthelemy Hugues, Reguiai Ziad, Bénéton Nathalie, Estève Eric, Chaby Guillaume, Ruer-Mulard Mireille, Steiner Henry-Georges, Thomas-Beaulieu Domitille, Avenel-Audran Martine, Goujon-Henry Catherine, Sigal Michele-Lea, Ezzedine Khaled, Beauchet Alain
Department of Dermatology, Bichat Claude Bernard Hospital, APHP Paris Diderot University 46 rue Henri Huchard, 75877 Paris Cedex 18, France.
Department of Dermatology, Hôpital Victor Dupouy, Argenteuil, France.
Eur J Dermatol. 2014 May-Jun;24(3):356-60. doi: 10.1684/ejd.2014.2346.
Whereas several studies have underlined the association between severe psoriasis and metabolic syndrome (MetS), the association of androgenetic alopecia (AGA) and MetS have yielded inconsistent results.
To investigate the relationship between AGA and the components of MetS in a population of psoriatic male patients.
A non-interventional, cross-sectional, multicenter study was conducted in France. A standardized questionnaire was completed, including information on components of MetS and other possible risk factors. MetS was defined in this study as a combination of three or more of the four components of MetS: waist circumference, hyperlipidemia, diabetes mellitus and hypertension. In addition, a standardized simplified Norwood classification limited into 5 grades (0-4) was used.
In a total of 1073 male patients, hypertension, high waist circumference, diabetes mellitus and hyperlipidemia were observed in 28%, 59%, 11%, and 31%, respectively. In age-adjusted multivariate analysis, severe AGA (grade 3-4 versus grade 0) was associated with the presence of at least one component of MetS. By groups of age, a statistically significant association of severe AGA and MetS was demonstrated in patients over 59 years. Severe AGA was also associated with a first degree familial history of major cardiovascular event in patients older than 59 years.
Our study, based on a simplified but stringent definition of MetS, confirmed the link between severe AGA and individual components of MetS in psoriatic patients. This argues for careful follow-up with regular screening in male psoriatic patients with severe AGA in order to early detect determinants of MetS.
尽管多项研究强调了重度银屑病与代谢综合征（MetS）之间的关联，但雄激素性脱发（AGA）与MetS的关联结果却不一致。
在银屑病男性患者群体中研究AGA与MetS各组分之间的关系。
在法国进行了一项非干预性、横断面、多中心研究。完成一份标准化问卷，包括有关MetS各组分及其他可能危险因素的信息。本研究中MetS被定义为MetS四个组分中三个或更多组分的组合：腰围、高脂血症、糖尿病和高血压。此外，使用了一种标准化的简化诺伍德分类法，分为5个等级（0 - 4级）。
在总共1073名男性患者中，高血压、高腰围、糖尿病和高脂血症的发生率分别为28%、59%、11%和31%。在年龄校正的多变量分析中，重度AGA（3 - 4级与0级相比）与至少一种MetS组分的存在相关。按年龄组划分，在59岁以上的患者中，重度AGA与MetS之间存在统计学显著关联。重度AGA还与59岁以上患者的重大心血管事件一级家族史相关。
我们基于对MetS简化但严格定义的研究，证实了重度AGA与银屑病患者MetS各单个组分之间的联系。这表明对于重度AGA的男性银屑病患者应进行仔细的随访并定期筛查，以便早期发现MetS的决定因素。
