Mahajan Ramit, Simon Ebby George
Department of Gastrointestinal Sciences, Christian Medical College, Vellore, 632004 Tamil Nadu India.
Indian J Clin Biochem. 2014 Apr;29(2):260-1. doi: 10.1007/s12291-013-0378-0. Epub 2013 Sep 4.
Hyponatremia is a common disorder in elderly and can result in changes in cognition, seizures, coma or even respiratory arrest if not recognised and treated. Syndrome of inappropriate anti diuretic hormone secretion (SIADH) is the most common cause of hyponatremia in elderly hospitalised patients and in most cases the etiology cannot be determined on routine investigations. We present a 76 year old male with symptomatic hyponatremia who had chronic urinary retention due to a urethral stricture. His sodium levels improved with catheterisation and worsened again after the catheter was removed. This supports the hypothesis that urinary retention and bladder distension can stimulate ADH release from the posterior pituitary, producing a picture similar to SIADH.
低钠血症在老年人中是一种常见病症,如果未被识别和治疗,可能会导致认知改变、癫痫发作、昏迷甚至呼吸骤停。抗利尿激素分泌不当综合征(SIADH)是老年住院患者低钠血症最常见的原因,在大多数情况下,病因无法通过常规检查确定。我们报告一例76岁男性有症状性低钠血症患者,该患者因尿道狭窄导致慢性尿潴留。导尿后其钠水平有所改善,但拔管后又再次恶化。这支持了尿潴留和膀胱扩张可刺激垂体后叶释放抗利尿激素,从而产生类似SIADH表现的假说。