一项关于妊娠肝内胆汁淤积症患者胎盘的病例对照研究。
A case-control review of placentas from patients with intrahepatic cholestasis of pregnancy.
作者信息
Patel Shivani, Pinheiro Meaghan, Felix Juan C, Opper Neisha, Ouzounian Joseph G, Lee Richard H
机构信息
1Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, CA, USA.
出版信息
Fetal Pediatr Pathol. 2014 Aug;33(4):210-5. doi: 10.3109/15513815.2014.899413. Epub 2014 Apr 23.
OBJECTIVE
To compare the incidence of histopathological features in placentas from women with cholestasis of pregnancy to healthy individuals without ICP.
METHODS
Placentas from mothers with and without cholestasis of pregnancy were reviewed by a pathologist masked to the study group. Subjects were excluded if they had medical problems already associated with placental histopathology.
RESULTS
Twenty-four cases and 30 controls placentas were reviewed. Seventeen placental histopathological features were found. There was no statistically significant difference between the groups. Amongst patients with cholestasis, there was a decrease in villitis of unknown etiology in those treated with ursodeoxycholic acid.
CONCLUSION
There is no difference in the placental histopathology in cholestasis of pregnancy compared to normal pregnancies, but treatment of patients with cholestasis of pregnancy with ursodeoxycholic acid may decrease findings of villitis of unknown etiology.
目的
比较妊娠肝内胆汁淤积症患者胎盘与无ICP的健康个体胎盘组织病理学特征的发生率。
方法
由对研究组不知情的病理学家对有和无妊娠肝内胆汁淤积症母亲的胎盘进行检查。如果受试者存在与胎盘组织病理学相关的医疗问题，则将其排除。
结果
对24例病例和30例对照胎盘进行了检查。发现了17种胎盘组织病理学特征。两组之间无统计学显著差异。在肝内胆汁淤积症患者中，接受熊去氧胆酸治疗的患者不明病因绒毛炎有所减少。
结论
与正常妊娠相比，妊娠肝内胆汁淤积症的胎盘组织病理学无差异，但用熊去氧胆酸治疗妊娠肝内胆汁淤积症患者可能会减少不明病因绒毛炎的表现。
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