Department of Obstetrics and Gynaecology, Karolinska Institutet, Danderyd Hospital, Stockholm, Sweden.
Placenta. 2012 Nov;33(11):914-8. doi: 10.1016/j.placenta.2012.08.005. Epub 2012 Sep 25.
To apply stereology for the detection of possibly morphological abnormalities in placentas of women with intrahepatic cholestasis of pregnancy (ICP).
Prospective case-control study of placentas from untreated and UDCA-treated ICP, respectively, and normal pregnancies, examined for morphological differences by systematic random sampling generated by computerized stereology methodology.
Volume of placenta, surface area of terminal villi and capillaries, volume fraction of collagen, number of syncytial knots, and chorangiosis.
Surface area of terminal villi and capillaries, and number of syncytial knots were higher in placentas from all ICP, as compared to controls (p < 0.01). A reduction of collagen was found in placentas from UDCA-treated ICP, both in comparison to placentas from untreated ICP and controls (p < 0.05).
ICP affects the placenta morphologically as shown by increased terminal villous and capillary surface area, and number of syncytial knots.
应用体视学方法检测未治疗的妊娠肝内胆汁淤积症（ICP）和熊去氧胆酸（UDCA）治疗的 ICP 及正常妊娠胎盘的形态学异常。
前瞻性病例对照研究，对未治疗的 ICP、UDCA 治疗的 ICP 和正常妊娠的胎盘进行形态学差异检查，采用计算机体视学方法进行系统随机抽样。
胎盘体积、终末绒毛表面积和毛细血管表面积、胶原体积分数、合体滋养层结节数和绒毛间质炎。
与对照组相比，所有 ICP 患者的胎盘终末绒毛和毛细血管表面积以及合体滋养层结节数均较高（p<0.01）。UDCA 治疗的 ICP 胎盘的胶原体积减少，与未治疗的 ICP 胎盘和对照组相比均有统计学差异（p<0.05）。
ICP 对胎盘有形态学影响，表现为终末绒毛和毛细血管表面积增加，合体滋养层结节数增加。
