红参提取物通过调节脂肪组织中 PKA 依赖性脂质动员来调节能量消耗。
Panax red ginseng extract regulates energy expenditures by modulating PKA dependent lipid mobilization in adipose tissue.
机构信息
Department of Biomedical Sciences, Cell Dysfunction Research Center (CDRC), University of Ulsan, College of Medicine, Seoul 138-736, Republic of Korea.
Department of Anatomy and Cell Biology, University of Ulsan, College of Medicine, Seoul 138-736, Republic of Korea.
出版信息
Biochem Biophys Res Commun. 2014 May 16;447(4):644-8. doi: 10.1016/j.bbrc.2014.04.056. Epub 2014 Apr 20.
Regulation of balance between lipid accumulation and energy consumption is a critical step for the maintenance of energy homeostasis. Here, we show that Panax red ginseng extract treatments increased energy expenditures and prevented mice from diet induced obesity. Panax red ginseng extracts strongly activated Hormone Specific Lipase (HSL) via Protein Kinase A (PKA). Since activation of HSL induces lipolysis in WAT and fatty acid oxidation in brown adipose tissue (BAT), these results suggest that Panax red ginseng extracts reduce HFD induced obesity by regulating lipid mobilization.
调节脂肪积累和能量消耗之间的平衡是维持能量稳态的关键步骤。在这里，我们表明，红参提取物处理可增加能量消耗并防止小鼠因饮食引起的肥胖。红参提取物通过蛋白激酶 A (PKA) 强烈激活激素特异性脂肪酶 (HSL)。由于 HSL 的激活会引发白色脂肪组织 (WAT) 的脂肪分解和棕色脂肪组织 (BAT) 的脂肪酸氧化，因此这些结果表明，红参提取物通过调节脂类动员来减少 HFD 诱导的肥胖。
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