Lipton S A, Kater S B
Trends Neurosci. 1989 Jul;12(7):265-70. doi: 10.1016/0166-2236(89)90026-x.
Molecules used for communication in mature nervous systems also play important roles in development, maintenance and plasticity of individual neurons. This paper reviews the evidence that neurotransmitters, in addition to their mediation of trans-synaptic information coding, can induce a spectrum of effects on neuronal cytoarchitecture, ranging from neurite sprouting to dendritic pruning and even cell death. Such profound alterations may well constitute a part of the normal functioning and structuring of the nervous system as well as contribute to severe pathological processes.
在成熟神经系统中用于通讯的分子，在单个神经元的发育、维持和可塑性方面也发挥着重要作用。本文综述了相关证据，即神经递质除了介导跨突触信息编码外，还能对神经元细胞结构产生一系列影响，从神经突萌发到树突修剪甚至细胞死亡。这种深刻的改变很可能构成神经系统正常功能和结构的一部分，同时也促成严重的病理过程。
