Sakalo V S, Klimenko I A, Iaremko V N, Zaparin V K
Urol Nefrol (Mosk). 1989 May-Jun(3):42-6.
The effect of combined treatment was studied in 97 patients with nonseminomatous testicular tumors with regional and distant metastases with regard to the blood serum levels of alpha-fetoprotein and chorionic gonadotropin. The disease stage was found closely correlating with the efficacy of the treatment and the level of tumor markers. Complete remission was observed in 84.2 per cent (16 out of 19) patients with normal marker levels and in 26.8 per cent (11 out of 41) of those in whom both markers levels were raised (p less than 0.05). A continuous follow-up revealed that increased marker levels were the evidence of tumor relapse or metastases in clinically silent patients.
对97例伴有区域和远处转移的非精原细胞瘤性睾丸肿瘤患者，就血清甲胎蛋白和绒毛膜促性腺激素水平进行了联合治疗效果的研究。发现疾病分期与治疗效果及肿瘤标志物水平密切相关。标志物水平正常的患者中84.2%（19例中的16例）实现完全缓解，而两种标志物水平均升高的患者中26.8%（41例中的11例）实现完全缓解（p<0.05）。持续随访显示，标志物水平升高是临床无症状患者肿瘤复发或转移的证据。
