Casacó A, Carbajal D, García M
National Center for Scientific Research (CENIC), Havana, Cuba.
Allergol Immunopathol (Madr). 1989 Mar-Apr;17(2):105-8.
The reasons for the frequent mutual exclusion in the same patient of asthma and diabetes and the fact that dextran anaphylactoid reaction does not occur in diabetic rats remain unknown. The mortality induced by the compound 48/80 and its histamine releasing effect from peritoneal mast cells have been tested in alloxan diabetic rats. The effect of acetylcholine on isolated airways from these animals has also been investigated. It is suggested that the lower quantity of peritoneal mast cells found in diabetic animals (and not the histamine released from its mast cells or airway hyporeactivity to acetylcholine) contributes to the protective effect of diabetes mellitus to the anaphylactoid reaction consequences.
哮喘与糖尿病在同一患者中频繁相互排斥的原因以及糖尿病大鼠不会发生右旋糖酐类过敏反应这一事实仍然未知。已在四氧嘧啶糖尿病大鼠中测试了化合物48/80诱导的死亡率及其从腹膜肥大细胞释放组胺的作用。还研究了乙酰胆碱对这些动物离体气道的影响。有人提出，糖尿病动物中腹膜肥大细胞数量较少（而非其肥大细胞释放的组胺或气道对乙酰胆碱的反应性降低）有助于糖尿病对类过敏反应后果的保护作用。
