Casacó A, Carvajal D, Tolón Z
Department of Pharmacology, National Center for Scientific Research, Cuidad de La Habana, Cuba.
Can J Physiol Pharmacol. 1991 Jun;69(6):886-8. doi: 10.1139/y91-134.
Rat mortality and contractile responses of isolated tracheas to compound 48/80 from rats made diabetic 4 days before by a single intravenous injection of alloxan and from diabetic rats that had been treated with insulin 6 h before were compared with control animals. Diabetic animals and tracheal segments from diabetic rats were significantly less responsive to compound 48/80 than control and insulin-treated diabetic animals. On the other hand, diabetic animals have a lower quantity of peritoneal mast cells than control rats, and insulin restored the normal quantity of cells in diabetic animals. These data indicate that diabetes elicits an hyposensitivity to compound 48/80, possibly related to a diabetes-induced decrease in the mast cell count.
将单次静脉注射四氧嘧啶4天前制成糖尿病的大鼠以及6小时前用胰岛素治疗的糖尿病大鼠的死亡率和离体气管对化合物48/80的收缩反应与对照动物进行比较。糖尿病动物和糖尿病大鼠的气管段对化合物48/80的反应明显低于对照动物和胰岛素治疗的糖尿病动物。另一方面，糖尿病动物腹膜肥大细胞的数量低于对照大鼠，而胰岛素可使糖尿病动物的细胞数量恢复正常。这些数据表明，糖尿病引起对化合物48/80的低敏感性，这可能与糖尿病诱导的肥大细胞数量减少有关。
