Lin Cheng-Ren, Li Lei, Ren Jian-Xun, Wang Min, Li Jun-Mei, Li Hong-Hai, Ge Zheng-Yan, Jin Long, Yao Ming-Jiang, Liu Jian-Xun
Zhongguo Zhong Yao Za Zhi. 2014 Jan;39(2):300-3.
To observe effect of formula of removing both phlegm and blood stasis (TYTZ) in improving hemorheology and blood fat of mini-swine with coronary heart disease of phlegm-stasis cementation syndrome.
Thirty-six Chinese mini-swine were randomly divided to six groups: the normal control group, the model group, the Shujiangzhi group and TYTZ groups with doses of 2.0, 1.0 and 0.5 g x kg(-1), with six mice in each group. Except for the normal control group, all of other groups were fed with high-fat diet for 2 weeks. Interventional balloons are adopted to injure their left anterior descending artery endothelium. After the operation, they were fed with high-fat diet for 8 weeks to prepare the coronary heart disease model of phlegm-stasis cementation syndrome. In the 8th week after the operation and administration, the changes in hemorheological parameters, serum lipid level, myocardial ischemia level and range were observed.
Compared with the normal control group, the model group showed significant increase in serum TC, TG, LDL-C and VLDL-C levels (P < 0.01), whole blood viscosity under the shear rate of 5 s (-1) and 60 s (-1) (P < 0.01), and myocardial ischemia degree and range (P < 0.01). Compared with the model group, TYTZ groups revealed significant decrease in myocardial ischemia degree and range (P < 0.01), serum TC, TG, LDL-C and VLDL-C levels (P < 0.05 or P < 0.01) and whole blood viscosity under the shear rate of 5 s(-1) and 60 s(-1) (P < 0.05).
TYTZ could improve the abnormal hemorheology in Chinese mini-swine with coronary heart disease of phlegm-stasis cementation syndrome, and regulate serum lipid, with a certain efficacy for coronary heart disease of phlegm-stasis cementation syndrome.
观察祛痰化瘀方（TYTZ）对痰瘀互结证冠心病小型猪血液流变学及血脂的改善作用。
将36只中国小型猪随机分为6组：正常对照组、模型组、舒降之组和剂量为2.0、1.0及0.5 g·kg⁻¹的TYTZ组，每组6只。除正常对照组外，其余各组均给予高脂饮食2周。采用介入球囊损伤其左前降支动脉内皮。术后给予高脂饮食8周以制备痰瘀互结证冠心病模型。在术后及给药第8周，观察血液流变学参数、血脂水平、心肌缺血程度及范围的变化。
与正常对照组比较，模型组血清总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）及极低密度脂蛋白胆固醇（VLDL-C）水平显著升高（P<0.01），切变率为5 s⁻¹和60 s⁻¹时的全血黏度显著升高（P<0.01），心肌缺血程度及范围显著增大（P<0.01）。与模型组比较，TYTZ组心肌缺血程度及范围显著减小（P<0.01），血清TC、TG、LDL-C及VLDL-C水平显著降低（P<0.05或P<0.01），切变率为5 s⁻¹和60 s⁻¹时的全血黏度显著降低（P<0.05）。
TYTZ可改善痰瘀互结证冠心病小型猪的血液流变学异常，调节血脂，对痰瘀互结证冠心病有一定疗效。
