白种人中DR4（肿瘤坏死因子相关凋亡诱导配体受体1）基因多态性与癌症风险的关联：一项更新的荟萃分析。

Association of DR4 (TRAIL-R1) polymorphisms with cancer risk in Caucasians: an updated meta-analysis.

作者信息

Chen Wei, Tang Wen-Ru, Zhang Ming, Chang Kwenjen, Wei Yun-Lin

机构信息

Faculty of Medicine, Kunming University of Science and Technology, Kunming, China E-mail :

出版信息

Asian Pac J Cancer Prev. 2014;15(6):2889-92. doi: 10.7314/apjcp.2014.15.6.2889.

DOI:10.7314/apjcp.2014.15.6.2889

PMID:24761920

Abstract

Death receptor 4 (TRAIL-R1 or DR4) polymorphisms have been associated with cancer risk, but findings have been inconsistent. To estimate the relationship in detail, a meta-analysis was here performed. A search of PubMed was conducted to investigate the association between DR4 C626G, A683C and A1322G polymorphisms and cancer risk, using odds ratios (ORs) with 95% confidence intervals. The results suggested that DR4 C626G and A683C polymorphisms were indeed associated with cancer risk (for C626G, dominant model, OR 0.991, 95%CI 0.866-1.133, p=0.015; for A683C, additive model, OR=1.140, 95%CI: 0.948-1.370, p=0.028; dominant model, OR=1.156, 95%CI: 0.950-1.406, p=0.080) in the Caucasian subgroup. However, the association was not significant between DR4 polymorphism A1322G with cancer risk in Caucasians (For A1322G, additive model: OR 1.085, 95%CI 0.931-1.289, p=0.217; dominant model: OR 1.379, 95%CI 0.934-2.035, p=0.311; recessive model: OR 1.026, 95%CI 0.831-1.268 p=0.429.). In summary, our finding suggests that DR4 polymorphism C626G and A683 rather than A1322G are associated with cancer risk in Caucasians.

摘要

死亡受体4（TRAIL-R1或DR4）基因多态性与癌症风险相关，但研究结果并不一致。为详细评估二者之间的关系，我们进行了一项荟萃分析。通过检索PubMed数据库，以比值比（OR）及其95%置信区间来研究DR4基因C626G、A683C和A1322G多态性与癌症风险之间的关联。结果表明，在高加索人群亚组中，DR4基因C626G和A683C多态性确实与癌症风险相关（对于C626G，显性模型，OR = 0.991，95%CI：0.866 - 1.133，p = 0.015；对于A683C，加性模型，OR = 1.140，95%CI：0.948 - 1.370，p = 0.028；显性模型，OR = 1.156，95%CI：0.950 - 1.406，p = 0.080）。然而，在高加索人群中，DR4基因A1322G多态性与癌症风险之间的关联并不显著（对于A1322G，加性模型：OR = 1.085，95%CI：0.931 - 1.289，p = 0.217；显性模型：OR = 1.379，95%CI：0.934 - 2.035，p = 0.311；隐性模型：OR = 1.026，95%CI：0.831 - 1.268，p = 0.429）。总之，我们的研究结果表明，在高加索人群中，与癌症风险相关的是DR4基因多态性C626G和A683，而非A1322G。