Sancini A, Casale T, De Sio S, Rosati M V, Sacco C, Montuori L, Nardone N, Giubilati R, Iannattone G, Nieto H A, Bonomi S, Tomei G, Tomei F, Caciari T
Department of Anatomy, Histology, Medical-Legal and the Orthopedics, Unit of Occupational Medicine, Sapienza University of Rome, Italy.
Department of Psychiatric and Psychological Science, Sapienza University of Rome, Italy.
Ann Ig. 2014 Mar-Apr;26(2):148-56. doi: 10.7416/ai.2014.1970.
High doses of organic solvents can cause hepatic disease. We investigated whether exposure to low doses of solvents in automotive and industrial workers may lead to changes in liver tests.
We studied the liver parameters (glutamic oxaloacetic transaminase (GOT), glutamic-pyruvic transaminase (GPT), gamma-glutamyl-traspeptidasi (γ-GT), alkaline phosphatase (PHA), total (TB) and direct bilirubin (DB) of 24 workers exposed to organic solvents and of 30 unexposed controls.
A significant increase of GOT, GPT and γ-GT was found in exposed workers compared to unexposed controls workers. The ratio GPT/GOT was significantly higher among the exposed compared to controls.
The results confirmed the hypothesis that exposure to low doses of solvents may determine a liver damage.
高剂量有机溶剂可导致肝脏疾病。我们调查了汽车和工业工人接触低剂量溶剂是否会导致肝功能检查结果发生变化。
我们研究了24名接触有机溶剂的工人和30名未接触溶剂的对照者的肝脏参数（谷草转氨酶（GOT）、谷丙转氨酶（GPT）、γ-谷氨酰转肽酶（γ-GT）、碱性磷酸酶（PHA）、总胆红素（TB）和直接胆红素（DB））。
与未接触溶剂的对照工人相比，接触溶剂的工人中GOT、GPT和γ-GT显著升高。与对照组相比，接触组的GPT/GOT比值显著更高。
结果证实了低剂量溶剂暴露可能导致肝损伤的假设。
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