Baumann M, Berauer M
Arch Toxicol Suppl. 1985;8:370-2. doi: 10.1007/978-3-642-69928-3_76.
In a short-term study the response of ornithine carbamyl transferase (OCT) was compared to that of glutamic oxalacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) in the serum of rats after treatment with single doses of carbon tetrachloride (CCl4). Furthermore, the sensitivity of gamma-glutamyl transpeptidase (gamma-GT) was studied in comparison to alkaline phosphatase (AP) and bilirubin. After dosing 100 microliter CCl4/kg, the response of OCT activity was 10- and 20-times higher than that of GOT and GPT, respectively. At 300 microliter/kg we observed an increase of up to 17- and 34-times of GOT and GPT activities. Maximal elevation of gamma-GT activity was about twice that of AP and of the bilirubin content. Moreover, the variability of the gamma-GT activities was found to be considerably higher, than that of AP and bilirubin levels. These results indicate, that OCT is a useful parameter to detect hepatic parenchymal injury, whereas gamma-GT cannot be proposed as an alternative to AP and bilirubin.
在一项短期研究中，比较了单剂量四氯化碳（CCl4）处理后大鼠血清中鸟氨酸氨甲酰转移酶（OCT）与谷氨酸草酰乙酸转氨酶（GOT）和谷氨酸丙酮酸转氨酶（GPT）的反应。此外，还研究了γ-谷氨酰转肽酶（γ-GT）与碱性磷酸酶（AP）和胆红素相比的敏感性。给予100微升CCl4 / kg后，OCT活性的反应分别比GOT和GPT高10倍和20倍。在300微升/千克时，我们观察到GOT和GPT活性分别增加了17倍和34倍。γ-GT活性的最大升高约为AP和胆红素含量的两倍。此外，发现γ-GT活性的变异性比AP和胆红素水平的变异性高得多。这些结果表明，OCT是检测肝实质损伤的有用参数，而γ-GT不能被提议作为AP和胆红素的替代指标。
