Iavicoli I, Fontana L, Iavicoli S
Istituto di Medicina del Lavoro, Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, 00168 Roma.
G Ital Med Lav Ergon. 2007 Jul-Sep;29(3 Suppl):271-2.
Isopropanol (IPA) is a volatile solvent that is used in many industrial process. The major symptoms of acute isopropanol toxicity include dizziness, incoordination, headache, hypothermia, eye ataxia, irritation of upper respiratory tract and shortness of breath. Vomiting, hematemesis, diarrhoea and hypotension may occur following accidental ingestion of IPA. No data regarding subchronic or chronic toxicity of IPA were identified. The aim of this study was to measure the serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and of gamma-glutamyltransferase (gamma-GT) of the last five years in 40 printer workers after the removal of IPA from the industry. The serum levels of ALT, AST and gamma-GT were higher in the exposed workers than in non exposed. In conclusion, the results of this study show that the removal of IPA from the industry had a positive health effect improving the hepatic function of the workers.
异丙醇（IPA）是一种挥发性溶剂，用于许多工业过程。急性异丙醇中毒的主要症状包括头晕、共济失调、头痛、体温过低、眼球运动失调、上呼吸道刺激和呼吸急促。意外摄入异丙醇后可能会出现呕吐、咯血、腹泻和低血压。未发现有关异丙醇亚慢性或慢性毒性的数据。本研究的目的是测量40名印刷工人在该行业去除异丙醇后的过去五年中血清丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）和γ-谷氨酰转移酶（γ-GT）的水平。暴露工人的ALT、AST和γ-GT血清水平高于未暴露工人。总之，本研究结果表明，该行业去除异丙醇对工人健康有积极影响，改善了他们的肝功能。
