儿童和青少年头颈部放疗后唾液腺和口腔黏膜的急性及晚期副作用。“儿童和青少年放疗副作用评估登记处”的结果
Acute and late side effects to salivary glands and oral mucosa after head and neck radiotherapy in children and adolescents. Results of the "Registry for the evaluation of side effects after radiotherapy in childhood and adolescence".
作者信息
Bölling Tobias, Weege Julia, Eich Hans Theodor, Timmermann Beate, Meyer Frank-Michal, Rübe Christian, Kortmann Rolf-Dieter, Fischedick Karin, Rödel Claus, Koch Raphael, Willich Normann
机构信息
Department of Radiotherapy, University Hospital of Münster, Münster, Germany.
Center for Radiotherapy Rheine/Osnabrück, Osnabrück, Germany.
出版信息
Head Neck. 2015 Aug;37(8):1137-41. doi: 10.1002/hed.23715. Epub 2014 Jul 11.
BACKGROUND
The registry for the evaluation of side effects after radiotherapy in childhood and adolescence (RiSK) was established to prospectively characterize radiation-associated side effects. The purpose of this analysis was to characterize side effects after radiotherapy to the head and neck in children and adolescents.
METHODS
Radiation doses have been collected across Germany since 2001. Acute and late side effects were characterized.
RESULTS
Until January 2010, 133 patients (median age, 12.7 years) were recruited who had received radiotherapy to the salivary glands. Toxicity evaluation was available for 114 patients (median follow-up, 2.9 years). Acute and late toxicity significantly depended on the maximum radiation dose to the salivary glands. An increase of the mean value of maximum dose of 1 Gray (Gy) to the submandibular glands resulted in an odds ratio of 1.04 (range, 1.00-1.08; p = .039) for acute toxicities of the salivary glands and 1.08 (range, 1.03-1.13; p = .001) for acute mucosal toxicities.
CONCLUSION
These data can be used for an individual risk assessment in pediatric head and neck radiotherapy.
背景
为前瞻性地描述放疗相关副作用，设立了儿童和青少年放疗后副作用评估登记处（RiSK）。本分析的目的是描述儿童和青少年头颈部放疗后的副作用。
方法
自2001年以来在德国收集了辐射剂量。对急性和晚期副作用进行了描述。
结果
截至2010年1月，招募了133例接受过唾液腺放疗的患者（中位年龄12.7岁）。对114例患者进行了毒性评估（中位随访时间2.9年）。急性和晚期毒性显著取决于唾液腺的最大辐射剂量。下颌下腺最大剂量平均值每增加1格雷（Gy），唾液腺急性毒性的比值比为1.04（范围1.00 - 1.08；p = 0.039），急性黏膜毒性的比值比为1.08（范围1.03 - 1.13；p = 0.001）。
结论
这些数据可用于儿童头颈部放疗的个体风险评估。
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