Potkin Vladimir I, Shcharbin Dzmitry, Denisov Andrey A, Paschkevich Svetlana G, Bryszewska Maria, Petkevich Sergey K, Kletskov Alexey V, Lapotko Dmitri O, Kazbanov Vladimir V, Gurinovich Tatiana A, Kulchitsky Vladimir A
Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus, Minsk, Belarus.
Cell Mol Biol Lett. 2014 Jun;19(2):243-8. doi: 10.2478/s11658-014-0193-5. Epub 2014 Apr 24.
We used complexes between a fourth generation polyamidoamine (PAMAM) dendrimer and one of two heterocyclic compounds - 1-(6-hydroxyhexyl)-3-(5-phenyl-isoxazole-3-yl)-urea or 5-phenyl-isoxazole-3-carboxylic acid - to reduce oxygen consumption in transverse slices of the hippocampus taken from 4-week old male rats. In vitro electrophysiological experiments revealed that the inhibitory effect of the hypoxic state on the evoked responses was enhanced in the presence of the complexes. The data were analyzed in terms of the potential antitumor effects of these complexes.
我们使用了第四代聚酰胺-胺（PAMAM）树枝状大分子与两种杂环化合物之一——1-(6-羟基己基)-3-(5-苯基异恶唑-3-基)脲或5-苯基异恶唑-3-羧酸形成的复合物，来降低取自4周龄雄性大鼠海马体的横向切片中的氧气消耗。体外电生理实验表明，在复合物存在的情况下，缺氧状态对诱发反应的抑制作用增强。根据这些复合物潜在的抗肿瘤作用对数据进行了分析。
