Kurahashi M, Inomata K
Department of Oral Physiology, School of Dentistry, Higashi-Nippon-Gakuen University, Hokkaido, Japan.
J Dent Res. 1989 Sep;68(9):1366-9. doi: 10.1177/00220345890680091501.
In order for the role of parotid amylase in starch digestion in the gastro-intestinal tracts of diabetic rats to be clarified, this study investigated the effect of parotid-duct ligation on both amylase secretion from the parotid glands and pancreas into the gastro-intestinal tract and on starch digestion in the gastro-intestinal contents during feedings. In both diabetic rats and control rats, parotid-duct ligation reduced amylase activity in both the parotid glands during fasting and in the gastric contents after feeding. The amylase activity in the intestinal contents after feeding was reduced by parotid-duct ligation in the diabetic rats. Starch digestion in the gastro-intestinal tract after feeding was reduced by parotid-duct ligation in the diabetic rats. The results suggest that most of the amylase activity in the gastric contents and a large part of the amylase activity in the intestinal contents are derived from the parotid glands, and that parotid amylase plays an important role in starch digestion in the gastro-intestinal tracts of diabetic rats.
为了阐明腮腺淀粉酶在糖尿病大鼠胃肠道淀粉消化中的作用，本研究调查了腮腺导管结扎对腮腺和胰腺向胃肠道分泌淀粉酶以及进食期间胃肠道内容物中淀粉消化的影响。在糖尿病大鼠和对照大鼠中，腮腺导管结扎均降低了禁食期间腮腺以及进食后胃内容物中的淀粉酶活性。糖尿病大鼠进食后肠道内容物中的淀粉酶活性因腮腺导管结扎而降低。糖尿病大鼠进食后胃肠道中的淀粉消化因腮腺导管结扎而减少。结果表明，胃内容物中的大部分淀粉酶活性以及肠道内容物中的大部分淀粉酶活性均来自腮腺，并且腮腺淀粉酶在糖尿病大鼠胃肠道的淀粉消化中起重要作用。
