Kurahashi M, Inomata K
Department of Oral Physiology, School of Dentistry, Higashi-Nippon-Gakuen University, Hokkaido, Japan.
Am J Physiol. 1988 Jun;254(6 Pt 1):G878-82. doi: 10.1152/ajpgi.1988.254.6.G878.
Parotid and pancreatic amylase secretion into the gastrointestinal tract during feeding was investigated in diabetic rats. In control rats, both parotid and pancreatic amylase activity decreased after feeding, while the amylase activity present in the gastric and small intestinal contents increased. In diabetic rats, parotid amylase activity, although reduced from control levels, decreased after feeding, and amylase activity of the parotid type appeared in the gastric content. Amylase activities in the diabetic pancreas and small intestinal contents at fasting were markedly reduced and did not show appreciable change with feeding. The total amylase activity in the small intestinal contents after feeding was markedly reduced in the diabetic rats, whereas the ratio of parotid to pancreatic amylase was markedly increased. These results suggest that the amylase secreted from the parotid glands into the gastrointestinal tract during feeding acts not only in the mouth and stomach but also in the small intestine of diabetic rats.
对糖尿病大鼠进食期间腮腺和胰腺淀粉酶向胃肠道的分泌情况进行了研究。在对照大鼠中，进食后腮腺和胰腺淀粉酶活性均下降，而胃和小肠内容物中的淀粉酶活性增加。在糖尿病大鼠中，腮腺淀粉酶活性虽低于对照水平，但进食后仍下降，且胃内容物中出现了腮腺型淀粉酶活性。糖尿病大鼠禁食时胰腺和小肠内容物中的淀粉酶活性显著降低，进食后无明显变化。糖尿病大鼠进食后小肠内容物中的总淀粉酶活性显著降低，而腮腺淀粉酶与胰腺淀粉酶的比例显著增加。这些结果表明，进食期间腮腺分泌到胃肠道的淀粉酶不仅在口腔和胃中起作用，而且在糖尿病大鼠的小肠中也起作用。
