Pap A, Nagy I, Takács T, Hajnal F, Tóth G, Varró V
1st Department of Medicine, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Int J Pancreatol. 1989 Oct;5(3):263-72. doi: 10.1007/BF02924471.
Influence of alcohol administration on the trophic effect of cholecystokinin-octapeptide and soybean trypsin inhibitor administration was examined in male Wistar rats. Two x 4 mL of 20% alcohol given intragastrically during 2 wk did not significantly influence pancreatic weight, DNA, protein, trypsin, chymotrypsin, amylase, lipase, or trypsin inhibitor contents of the pancreas. It diminished the hypertrophy but not the hyperplasia seen after CCK-8 treatment, and eliminated the hyperplasia, as well as the hypertrophy provoked by SBTI administration. Secretory studies and CCK measurements demonstrated decreased CCK release in response to SBTI stimulation after 3-d alcohol administration. The results indicate that alcohol inhibits the enzyme synthesis of the CCK stimulated dividing and/or newly formed acinar cells and the endogenous CCK release.
在雄性Wistar大鼠中研究了给予酒精对胆囊收缩素八肽和大豆胰蛋白酶抑制剂营养作用的影响。在2周内通过胃内给予2×4 mL 20%的酒精，对胰腺重量、胰腺DNA、蛋白质、胰蛋白酶、糜蛋白酶、淀粉酶、脂肪酶或胰蛋白酶抑制剂含量没有显著影响。它减少了CCK-8治疗后出现的肥大，但没有减少增生，并且消除了SBTI给药引起的增生和肥大。分泌研究和CCK测量表明，在给予酒精3天后，对SBTI刺激的CCK释放减少。结果表明，酒精抑制CCK刺激的分裂和/或新形成的腺泡细胞的酶合成以及内源性CCK释放。
